Negative Correlation between Urinary Selenium and Arsenic Levels of the Residents Living in an Arsenic-Contaminated Area in Bangladesh
Negative Correlation between Urinary Selenium and Arsenic Levels of the Residents Living in an Arsenic-Contaminated Area in Bangladesh
复制标题
孟加拉国砷污染地区居民尿硒与砷水平呈负相关
DOI：
10.1248/jhs.49.239
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发表时间：
2003
影响因子：
--
通讯作者：
R. Ohtsuka
中科院分区：
文献类型：
--
作者：
Kaori Miyazaki;Kayo Ushijima;Takefumi Kadono;T. Inaoka;C. Watanabe;R. Ohtsuka
许多实验研究报道了硒(Se)和砷(As)的毒理和代谢相互作用。然而，对于人类群体来说，砷和硒之间可能的相互作用及其毒理学意义尚未确定。在这项研究中，我们研究了从孟加拉国东北部两个农村社区的居民采集的现场尿样中Se和As的关系。用氢化物发生原子吸收光谱法(HGAAS)测定尿砷(UAS)和硒(USE)浓度。在男性和女性中，UAS与使用呈负相关。考虑到这些社区的暴露条件，这种相关性不太可能反映出这些元素的摄入量之间的相关性。这一结果表明，接触饮用水或食物可能会改变人体的硒代谢。讨论了这种相互作用可能的毒理学意义。
Toxicological and metabolic interactions of selenium (Se) with arsenic (As) have been reported in many experimental studies. However, for human populations, possible interactions between As and Se and their toxicological significance have not been established. In this study, we have examined the relationship between Se and As in spot urine samples collected from the inhabitants of two rural communities of northeast Bangladesh. The urinary As (UAs) and Se (USe) concentrations were determined by hydride generation atomic absorption spectrometry (HGAAS). Negative correlation between UAs and USe was found in both males and females. Considering the exposure condition in these communities, it is unlikely that the correlation reflected the correlation between the intakes of these elements. This result suggests that As exposure from drinking water or food may change Se metabolism in humans. Possible toxicological significance of the interaction is discussed.
砷对大鼠硒代谢和谷胱甘肽过氧化物酶活性的影响。
DOI：
--
发表时间：
1991
期刊：
Journal of trace elements and electrolytes in health and disease
影响因子：
--
作者：
Pederson,ND;Butler,JA;Whanger,PD
通讯作者：
Whanger,PD
影响因子：
11.1
作者：
Allan H. Smith;Elena O Lingas;Mahfuzar Rahman
通讯作者：
Allan H. Smith;Elena O Lingas;Mahfuzar Rahman
影响因子：
5
作者：
Smith, AH;Goycolea, M;Biggs, ML
通讯作者：
Biggs, ML