Cerebral Critical Closing Pressure in Concomitant Traumatic Brain Injury and Intracranial Hematomas.
Cerebral Critical Closing Pressure in Concomitant Traumatic Brain Injury and Intracranial Hematomas.
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DOI：
10.1007/978-3-030-78787-5_5
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发表时间：
2021
影响因子：
--
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中科院分区：
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临界闭合压力（CrCP）是指低于该压力时，局部软脑膜血压不足以防止血流停止的压力。脑CrCP在合并创伤性脑损伤（TBI）和颅内血肿（TBI + ICH）中的研究尚不充分。目的是确定在有和没有ICH开发的情况下cTBI时CrCP的状态。材料和方法。研究了90例重度至中度cTBI患者的治疗结果（男/女-49：41）。平均年龄为34.2 ± 14.4岁。根据是否存在ICH，将患者分为两组。所有患者均行双侧大脑中动脉经颅多普勒检查，并测定平均动脉压（MAP）。根据获得的数据，计算了CrCP。显著性预设为p < 0.05。结果各组的平均CrCP值似乎显著高于参考值（p < 0.05）。清除血肿的病灶周围区的平均CrCP值显著高于无ICH的TBI患者（分别为p = 0.015和p = 0.048）。不同类型脑出血患者的CrCP值差异无统计学意义（p > 0.05）。讨论CrCP在伴有和不伴有ICH的TBI患者组中存在显著差异。各组在伴随损伤结构方面的可比性证明，所揭示的CrCP变化是由脑创伤性压迫引起的。
The critical closing pressure (CrCP) is the pressure below which the local pial blood pressure is inadequate to prevent blood flow cessation. The cerebral CrCP in concomitant traumatic brain injury (TBI) and intracranial hematomas (TBI + ICH) remains understudied. The aim was to determine the status of the CrCP at cTBI with and without the ICH development. Material and methods. The results of the treatment of 90 patients with severe to moderate cTBI were studied (male/female – 49:41). The average age was 34.2 ± 14.4 years. Depending on the presence of ICH, patients were divided into two groups. All patients were subjected to transcranial Doppler of the both middle cerebral arteries, and evaluation of mean arterial pressure (MAP). Based on data obtained, the CrCPs were calculated. Significance was preset to p < 0.05. Results. The mean CrCP values in each group appeared to be significantly higher than a referral value (p < 0.05). The mean CrCP values in the peri-focal zone of removed hematoma were significantly higher than in TBI patients without ICH (p = 0.015 and p = 0.048, respectively). Analysis of CrCP values in various types of ICH showed no statistically significant differences (p > 0.05). Discussion. The CrCP significantly differs in the groups of TBI patients with and without ICH. The comparability of the groups in respect to the concomitant injury structure proves that the revealed CrCP changes result from the traumatic compression of the brain.
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影响因子：
1.4
作者：
O'Brien, Nicole F.;Lovett, Marlina E.;Maa, Tensing
通讯作者：
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影响因子：
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DOI：
10.1016/j.jstrokecerebrovasdis.2017.02.026
发表时间：
2017-05-01
影响因子：
2.5
作者：
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通讯作者：
Bor-Seng-Shu, E.
影响因子：
2.4
作者：
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通讯作者：
Pickard, JD