Up-regulation of GTSE1 lacks a relationship with clinical data in lung cancer.
Up-regulation of GTSE1 lacks a relationship with clinical data in lung cancer.
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GTSE1 的上调与肺癌的临床数据缺乏关系。
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发表时间：
2011
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肺癌是导致世界各地癌症患者死亡的最常见癌症类型之一。明确差异表达基因对于肺癌的诊断和治疗至关重要。根据公共cDNA微阵列数据库，我们发现GTSE1在肺癌患者组织中显着过度表达。为了进一步验证微阵列数据，采用定量实时 PCR 和免疫组织化学染色来测试 GTSE1 在 mRNA 和蛋白质水平上的表达。与邻近正常组织相比，GTSE1在肺癌组织中表达上调，尤其是在腺癌和鳞状细胞癌中。研究了 GTSE1 的表达谱，并在 246 名肺癌患者中评估了 GTSE1 的临床意义以及与总生存期之间的关联。然而，GTSE1、临床特征和生存率之间没有观察到统计学上显着的相关性。因此，GTSE1 可能不是肺癌的预后标志物。
Lung cancer is one of the most common cancer types that lead to death in cancer patients across the world. Clarification of differentially expressed genes is essential for lung cancer diagnosis and treatment. According to the public cDNA microarray database, we found that GTSE1 is overexpressed dramatically in lung cancer patients' tissues. To further verify the microarray data, quantitative real-time PCR and immunohistochemical staining was undertaken to test GTSE1 expression both at mRNA and protein levels. GTSE1 is up-regulated in lung cancer tissues compared to the adjacent normal tissues, especially in adenocarcinoma and squamous cell carcinoma. The expression profile of GTSE1 was investigated, and the clinical significance and the association between GTSE1 and the overall survival assessed in 246 lung cancer patients. No statistically significant correlation, however, was observed between GTSE1, the clinical features and survival. Thus, GTSE1 may not be a prognostic marker in lung cancers.
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影响因子：
4.8
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