Fraction-variant beam orientation optimization for intensity-modulated proton therapy.
Fraction-variant beam orientation optimization for intensity-modulated proton therapy.
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DOI：
10.1002/mp.14340
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发表时间：
2020-09
期刊：
影响因子：
3.8
通讯作者：
Sheng K
中科院分区：
文献类型：
--
作者：
Gu W;O'Connor D;Ruan D;Zou W;Dong L;Sheng K
为了在剂量学和强度调制质子疗法(IMPT)的传输效率之间实现最佳平衡，在单个部分中使用尽可能少的束流，我们在不同的部分中最佳地改变束流。在优化过程中，候选库中包含了400~800个可行的非共面波束。对于每个射束，计算覆盖目标体积和边缘的所有扫描点的剂量。建立了分数变射束定向优化问题(FVBOO)，包括三个项：两个二次剂量保真项，分别惩罚计划目标体积分数剂量和危险器官(OAR)累积剂量与处方的偏差；一个L2，1/2范数组稀疏项，将每个分数的有效射束数控制在1到4之间。对1例颅底肿瘤5个部位(5f)和30个部位(30f)的患者进行了FVBOO检测，平均每个部位的有效射束数在4~1个之间。另外，对1例双侧头颈部(H&N)患者和1例30f的食道癌(ESG)患者进行了每部分约3个有效射束的测试。将结果与在每个部分使用固定光束的IMPT计划进行了比较。使用带有分数不变Boo(FIBOO)约束的群稀疏项来选择固定光束。在5f或30f FVBOO计划中选择了不同的光束。在FIBOO方案中，FVBOO方案与FIBOO方案相比，平均减少了[Dean，Dmax]，在5f方案中平均减少了[0.85，2.08]相对生物有效射线(GyRBE)，在30f方案中平均减少了[1.87，4.06]GyRBE。在减少BOS患者每部分的射束数量的同时，三射束/分割5f FVBOO计划的表现与四射束FIBOO计划和双射束/分割30f FVBOO计划的表现相当，仍然提供了优越的剂量学。分段可变束流定向优化允许利用更大的束流解决方案空间来实现IMPT中的最佳剂量分布，同时保持每个分段中的实际束流数目。
To achieve a superior balance between dosimetry and the delivery efficiency of intensity-modulated proton therapy (IMPT) using as few beams as possible in a single fraction, we optimally vary beams in different fractions. In the optimization, 400~800 feasible noncoplanar beams were included in the candidate pool. For each beam, the doses of all scanning spots covering the target volume and a margin were calculated. The fraction-variant beam orientation optimization (FVBOO) problem was formulated to include three terms: two quadratic dose fidelity terms to penalize the deviation of planning target volume fractional dose and organs at risk (OAR) cumulative doses from prescription, respectively; an L2,1/2-norm group sparsity term to control the number of active beams per fraction to between 1 and 4. The Fast Iterative Shrinkage-Thresholding Algorithm (FISTA) was applied to solve this problem. FVBOO was tested on a patient with base-of-skull (BOS) tumor of 5 fractions (5f) and 30 fractions (30f) with an average number of active beams per fraction varying between 4 and 1. In addition, one bilateral head-and-neck (H&N) patient, and one esophageal cancer (ESG) patient of 30f were tested with about three active beams per fraction. The results were compared with IMPT plans that use fixed beams in each fraction. The fixed beams were selected using the group sparsity term with a fraction-invariant BOO (FIBOO) constraint. Varying beams were chosen in either the 5f or 30f FVBOO plans. While similar number of beams per fraction was selected as the FIBOO plan, the FVBOO plans were able to spare the OARs better, with an average reduction of [Dmean, Dmax] from the FIBOO plans by [0.85, 2.08] Relative Biological Effective Gy (GyRBE) in the 5f plan and [1.87, 4.06] GyRBE in the 30f plans. While reducing the number of beams per fraction in the BOS patient, a three-beam/fraction 5f FVBOO plan performs comparably as the four-beam FIBOO plan and a two-beam/fraction 30f FVBOO plan still provides superior dosimetry. Fraction-variant beam orientation optimization allows the utilization of a larger beam solution space for superior dose distribution in IMPT while maintaining a practical number of beams in each fraction.
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影响因子：
5.7
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