Intrinsic signal optical imaging of brain function using short stimulus delivery intervals.
Intrinsic signal optical imaging of brain function using short stimulus delivery intervals.
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DOI：
10.1016/j.jneumeth.2010.01.009
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发表时间：
2010-03-30
影响因子：
3
通讯作者：
Frostig, Ron D.
中科院分区：
文献类型：
--
作者：
Chen-Bee, Cynthia H.;Agoncillo, Teodora;Lay, Christopher C.;Frostig, Ron D.
关键词：
Intrinsic Signal Optical Imaging (ISOI) can be used to map cortical function and organization. Because its detected signal lasts 10+ sec consisting of three phases, trials are typically collected using a long (tens of seconds) stimulus delivery interval (SDI) at the expense of efficiency, even when interested in mapping only the first signal phase (e.g., ISOI initial dip). It is unclear how the activity profile can change when stimuli are delivered at shorter intervals, and whether a short SDI can be implemented to improve efficiency. The goals of the present study are two-fold: characterize the ISOI activity profile when multiple stimuli are delivered at 4 sec intervals, and determine whether successful mapping can be attained from trials collected using an SDI of 4 sec (offering >10× increase in efficiency). Our results indicate that four stimuli delivered 4 sec apart evoke an activity profile different from the triphasic signal, consisting of signal dips in a series at the same frequency as the stimuli despite a strong rise in signal prior to the 2nd–4th stimuli. Visualization of such signal dips is dependent on using a baseline immediately prior to every stimulus. Use of the 4-sec SDI is confirmed to successfully map activity with a similar location in peak activity and increased areal extent and peak magnitude compared to using a long SDI. Additional experiments were performed to begin addressing issues such as SDI temporal jittering, response magnitude as a function of SDI duration, and application for successful mapping of cortical function topography.
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影响因子：
5.3
作者：
Chen-Bee, Cynthia H.;Agoncillo, Teodora;Frostig, Ron D.
通讯作者：
Frostig, Ron D.
影响因子：
3
作者：
ChenBee, CH;Kwon, MC;Frostig, RD
通讯作者：
Frostig, RD
影响因子：
64.8
作者：
GRINVALD, A;LIEKE, E;WIESEL, TN
通讯作者：
WIESEL, TN
DOI：
10.1073/pnas.87.16.6082
发表时间：
1990-08-01
影响因子：
11.1
作者：
FROSTIG, RD;LIEKE, EE;GRINVALD, A
通讯作者：
GRINVALD, A
影响因子：
5.3
作者：
Brett-Green, BA;Chen-Bee, CH;Frostig, RD
通讯作者：
Frostig, RD