Comparative genomic analysis of three Leishmania species that cause diverse human disease.
Comparative genomic analysis of three Leishmania species that cause diverse human disease.
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作者：
利什曼原虫寄生虫引起广泛的临床疾病。在这里，我们报告了两种利什曼原虫的基因组测序：婴儿利什曼原虫和巴西利什曼原虫。将这些序列与已发表的大利什曼原虫基因组进行比较，揭示了显着的同线性保守性，并仅鉴定出约 200 个基因在三个物种之间具有差异分布。与迄今为止检查的利什曼原虫物种相反，巴西利什曼原虫拥有假定的 RNA 介导的干扰途径的成分、端粒相关的转座元件和剪接前导相关的 SLACS 逆转录转座子。我们表明，假基因的形成和基因丢失是塑造不同基因组的主要力量。物种间差异分布的基因编码与宿主-病原体相互作用和寄生虫在巨噬细胞中的存活有关的蛋白质。
Leishmania parasites cause a broad spectrum of clinical disease. Here we report the sequencing of the genomes of two species of Leishmania: Leishmania infantum and Leishmania braziliensis. The comparison of these sequences with the published genome of Leishmania major reveals marked conservation of synteny and identifies only ∼200 genes with a differential distribution between the three species. L. braziliensis, contrary to Leishmania species examined so far, possesses components of a putative RNA-mediated interference pathway, telomere-associated transposable elements and spliced leader–associated SLACS retrotransposons. We show that pseudogene formation and gene loss are the principal forces shaping the different genomes. Genes that are differentially distributed between the species encode proteins implicated in host-pathogen interactions and parasite survival in the macrophage.
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影响因子：
1.5
作者：
Durand-Dubief, M;Kohl, L;Bastin, P
通讯作者：
Bastin, P
影响因子：
4.8
作者：
Jones, SM;Alb, JG;Howell, KE
通讯作者：
Howell, KE
影响因子：
4.1
作者：
Knuepfer, E;Stierhof, YD;Smith, DF
通讯作者：
Smith, DF
影响因子：
56.9
作者：
Ivens, AC;Peacock, CS;Myler, PJ
通讯作者：
Myler, PJ
DOI：
10.1016/0035-9203(86)90243-9
发表时间：
1986-01-01
影响因子：
2.2
作者：
MARSDEN, PD
通讯作者：
MARSDEN, PD