Extracellular vesicles as personalized medicine.
Extracellular vesicles as personalized medicine.
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细胞外囊泡作为个性化医学。
DOI：
10.1016/j.mam.2022.101155
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发表时间：
2023-06
影响因子：
10.6
通讯作者：
Fairweather, DeLisa
中科院分区：
文献类型：
--
作者：
Beetler, Danielle J.;Di Florio, Damian N.;Bruno, Katelyn A.;Ikezu, Tsuneya;March, Keith L.;Cooper Jr., Leslie T.;Wolfram, Joy;Fairweather, DeLisa
细胞外囊泡（EV）从体内所有细胞释放，形成重要的细胞间通讯网络，有助于健康和疾病。EV的内容物是细胞源特异性的，在受体细胞中诱导不同的信号传导反应。EV的特异性及其在液体活检可接近的液体空间中的积累使其作为潜在的生物标志物和疾病治疗方法极具吸引力。EV作为有利（治疗）或不利（病理）信使的双重性是背景依赖性的，并且在稳态和各种疾病状态中仍有待完全确定。这篇综述描述了EV作为生物标志物、药物递送载体和再生治疗剂的用途，突出了涉及病毒感染、癌症和神经系统疾病的例子。人们越来越关注基于个体患者和疾病特征提供个性化治疗。越来越多的证据表明，由于EV的多样性和多功能性，EV生物标志物和治疗方法是个性化医疗的理想选择。
Extracellular vesicles (EVs) are released from all cells in the body, forming an important intercellular communication network that contributes to health and disease. The contents of EVs are cell source-specific, inducing distinct signaling responses in recipient cells. The specificity of EVs and their accumulation in fluid spaces that are accessible for liquid biopsies make them highly attractive as potential biomarkers and therapies for disease. The duality of EVs as favorable (therapeutic) or unfavorable (pathological) messengers is context dependent and remains to be fully determined in homeostasis and various disease states. This review describes the use of EVs as biomarkers, drug delivery vehicles, and regenerative therapeutics, highlighting examples involving viral infections, cancer, and neurological diseases. There is growing interest to provide personalized therapy based on individual patient and disease characteristics. Increasing evidence suggests that EV biomarkers and therapeutic approaches are ideal for personalized medicine due to the diversity and multifunctionality of EVs.
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细胞外囊泡作为治疗慢性伤口的治疗工具。
影响因子：
5.4
作者：
Bray ER;Oropallo AR;Grande DA;Kirsner RS;Badiavas EV
通讯作者：
Badiavas EV
影响因子：
10.2
作者：
Busatto S;Yang Y;Walker SA;Davidovich I;Lin WH;Lewis-Tuffin L;Anastasiadis PZ;Sarkaria J;Talmon Y;Wurtz G;Wolfram J
通讯作者：
Wolfram J
影响因子：
4.8
作者：
Bakhti, Mostafa;Winter, Christine;Simons, Mikael
通讯作者：
Simons, Mikael
影响因子：
5.3
作者：
Bonafede R;Mariotti R
通讯作者：
Mariotti R
影响因子：
5.4
作者：
Bashratyan, Roman;Sheng, Huiming;Regn, Danielle;Rahman, M. Jubayer;Dai, Yang D.
通讯作者：
Dai, Yang D.