Brain metastases-derived extracellular vesicles induce binding and aggregation of low-density lipoprotein.
Brain metastases-derived extracellular vesicles induce binding and aggregation of low-density lipoprotein.
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DOI：
10.1186/s12951-020-00722-2
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发表时间：
2020-11-07
影响因子：
10.2
通讯作者：
Wolfram J
中科院分区：
文献类型：
--
作者：
Busatto S;Yang Y;Walker SA;Davidovich I;Lin WH;Lewis-Tuffin L;Anastasiadis PZ;Sarkaria J;Talmon Y;Wurtz G;Wolfram J
癌细胞来源的细胞外囊泡（EVs）先前已被证明有助于转移前生态位的形成。具体来说，侵袭性肿瘤分泌促转移性ev，这些ev通过循环传播到远处的器官，调节微环境，为未来的转移扩散做好准备。先前的研究主要集中在转移前生态位中促转移性ev和上皮/内皮细胞之间的界面。然而，EV与循环成分如低密度脂蛋白（LDL）的相互作用一直被忽视。本研究表明，脑转移细胞（br - ev）和相应的常规癌细胞（reg - ev）衍生的ev与LDL的相互作用不同。具体来说，Br-EV触发LDL聚集，LDL的存在加速了Br-EV被单核细胞摄取，而单核细胞是脑转移生态位的关键成分。总的来说，这些数据首次证明了促转移性ev与LDL表现出明显的相互作用，这影响了ev的单核细胞内化。
Cancer cell-derived extracellular vesicles (EVs) have previously been shown to contribute to pre-metastatic niche formation. Specifically, aggressive tumors secrete pro-metastatic EVs that travel in the circulation to distant organs to modulate the microenvironment for future metastatic spread. Previous studies have focused on the interface between pro-metastatic EVs and epithelial/endothelial cells in the pre-metastatic niche. However, EV interactions with circulating components such as low-density lipoprotein (LDL) have been overlooked. This study demonstrates that EVs derived from brain metastases cells (Br-EVs) and corresponding regular cancer cells (Reg-EVs) display different interactions with LDL. Specifically, Br-EVs trigger LDL aggregation, and the presence of LDL accelerates Br-EV uptake by monocytes, which are key components in the brain metastatic niche. Collectively, these data are the first to demonstrate that pro-metastatic EVs display distinct interactions with LDL, which impacts monocyte internalization of EVs.
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影响因子：
5.4
作者：
Deregibus MC;Figliolini F;D'Antico S;Manzini PM;Pasquino C;De Lena M;Tetta C;Brizzi MF;Camussi G
通讯作者：
Camussi G
影响因子：
21.3
作者：
Costa-Silva B;Aiello NM;Ocean AJ;Singh S;Zhang H;Thakur BK;Becker A;Hoshino A;Mark MT;Molina H;Xiang J;Zhang T;Theilen TM;García-Santos G;Williams C;Ararso Y;Huang Y;Rodrigues G;Shen TL;Labori KJ;Lothe IM;Kure EH;Hernandez J;Doussot A;Ebbesen SH;Grandgenett PM;Hollingsworth MA;Jain M;Mallya K;Batra SK;Jarnagin WR;Schwartz RE;Matei I;Peinado H;Stanger BZ;Bromberg J;Lyden D
通讯作者：
Lyden D
影响因子：
50.3
作者：
Becker A;Thakur BK;Weiss JM;Kim HS;Peinado H;Lyden D
通讯作者：
Lyden D
影响因子：
2.8
作者：
Busatto, Sara;Pham, Anthony;Wolfram, Joy
通讯作者：
Wolfram, Joy
影响因子：
16
作者：
Boing, Anita N.;van der Pol, Edwin;Nieuwland, Rienk
通讯作者：
Nieuwland, Rienk