Molecular and biological role of the FOXP3 N-terminal domain in immune regulation by T regulatory/suppressor cells.
Molecular and biological role of the FOXP3 N-terminal domain in immune regulation by T regulatory/suppressor cells.
复制标题
DOI：
10.1016/j.yexmp.2012.09.013
复制
发表时间：
2012-12
影响因子：
3.6
通讯作者：
Greene, Mark I.
中科院分区：
文献类型：
--
作者：
Deng, Guoping;Xiao, Yan;Zhou, Zhaocai;Nagai, Yasuhiro;Zhang, Hongtao;Li, Bin;Greene, Mark I.
调节性T （Treg）细胞在防止宿主发生某些自身免疫性疾病和限制对病原体的过度免疫反应方面是必不可少的。大多数Treg细胞的正常功能需要功能性FOXP3的持续表达，FOXP3是foxxp家族转录因子的一员。FOXP3不同于其他亚家族成员，因为它独特的富含脯氨酸的氨基末端结构域。在某些x连锁自身免疫-过敏性失调综合征（XLAAD）患者中偶尔发现该区域的突变，类似的突变也会增加啮齿动物模型中自身免疫性疾病的易感性。先前对FOXP3 N-结构域的分析揭示了其在核输入、与其他转录因子的相互作用以及作为FOXP3特定翻译后修饰位点的作用，这些修饰位点有助于FOXP3的稳定性。
Regulatory T (Treg) cells are essential in preventing the host from developing certain autoimmune diseases and limiting excessive immune responses against pathogens. The normal function of most Treg cells requires sustained expression of functional FOXP3, a member of the FOXP family transcription factors. FOXP3 is distinct from other subfamily members because of its unique proline rich amino (N)-terminal domain. Mutations in this region are occasionally identified in certain patients with X-linked autoimmunity–allergic dysregulation syndrome (XLAAD) and similar mutations also increase susceptibility of autoimmune diseases in rodent models. Previous analyses of the FOXP3 N- domain revealed a role in nuclear import, interaction with other transcription factors, and as sites of specific post-translational modifications of FOXP3 that contribute to FOXP3 stability.
登录
查看更多内容
影响因子：
32.4
作者：
Fontenot, JD;Rasmussen, JP;Rudensky, AY
通讯作者：
Rudensky, AY
影响因子：
3.7
作者：
Loizou L;Andersen KG;Betz AG
通讯作者：
Betz AG
DOI：
10.1073/pnas.0700298104
发表时间：
2007-03-13
影响因子：
11.1
作者：
Li, Bin;Samanta, Arabinda;Greene, Mark I.
通讯作者：
Greene, Mark I.
影响因子：
64.8
作者：
KALDERON, D;RICHARDSON, WD;SMITH, AE
通讯作者：
SMITH, AE
影响因子：
3.2
作者：
Bennett, CL;Brunkow, ME;Chance, PF
通讯作者：
Chance, PF