Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China.
Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China.
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DOI：
10.1186/1471-2407-9-269
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发表时间：
2009-08-05
期刊：
影响因子：
3.8
通讯作者：
Taylor P
中科院分区：
文献类型：
--
作者：
Gao Y;Hu N;Han X;Giffen C;Ding T;Goldstein A;Taylor P
不同亲属类型的家族史（FH）和上消化道（UGI）癌症的风险很少有报道；关于上消化道癌症生存率的数据很少。 600 例食管鳞状细胞癌 (ESCC) 病例、598 例胃贲门腺癌病例、316 例胃非贲门腺癌病例以及 1514 例年龄、性别和邻里匹配的对照者被询问一级亲属和非血亲中是否有 FH。估计了逻辑回归的比值比 (OR) 和 95% 置信区间 (CI)，以及 Cox 比例风险回归的风险比 (HR)。 ESCC风险增加与任何癌症的FH（OR = 1.72，95% CI = 1.39–2.12）、任何UGI癌症的FH（OR = 2.28，95% CI = 1.77–2.95）和食管癌的FH（OR = 2.84，95% CI = 2.09–3.86）相关，但与非UGI癌症的FH无关癌症。有两个或两个以上一级亲属受影响的个体，食管鳞癌的风险增加 10 倍。贲门癌 FH 与所有三种癌症的风险增加相关。非血缘亲属的癌症与任何上消化道癌症的风险无关。 UGI 癌 FH 与年轻 ESCC 病例的较差生存率相关（HR = 1.82，95% CI = 1.01–3.29）。这些数据提供了强有力的证据，表明共同的易感性与食管癌的发生有关，并且还表明其在预后中的作用。
Family history (FH) by different relative types and risk of upper gastrointestinal (UGI) cancers has been only rarely reported; the data on UGI cancer survival are sparse. 600 esophageal squamous cell carcinoma (ESCC) cases, 598 gastric cardia adenocarcinoma cases, and 316 gastric non-cardia adenocarcinoma cases, and 1514 age-, gender-, and neighborhood-matched controls were asked for FH in first degree relatives and non-blood relatives. Odds ratios (ORs) and 95% confidence intervals (CIs) from logistic regressions, and hazard ratios (HRs) from Cox proportional hazard regressions were estimated. Increased ESCC risk was associated with FH of any cancer (OR = 1.72, 95% CI = 1.39–2.12), FH of any UGI cancer (OR = 2.28, 95%CI = 1.77–2.95) and FH of esophageal cancer (OR = 2.84, 95%CI = 2.09–3.86), but not FH of non-UGI cancer. Individuals with two or more affected first-degree relatives had 10-fold increased ESCC risk. FH of gastric cardia cancer was associated with an increased risk of all three cancers. Cancer in non-blood relatives was not associated with risk of any UGI cancer. FH of UGI cancer was associated with a poorer survival rate among younger ESCC cases (HR = 1.82, 95%CI = 1.01–3.29). These data provide strong evidence that shared susceptibility is involved in esophageal carcinogenesis and also suggest a role in prognosis.
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影响因子：
120.7
作者：
Chan, Jennifer A.;Meyerhardt, Jeffrey A.;Fuchs, Charles S.
通讯作者：
Fuchs, Charles S.
DOI：
10.1111/j.1349-7006.1992.tb00127.x
发表时间：
1992-06
期刊：
Japanese journal of cancer research : Gann
影响因子：
--
作者：
Kato I;Tominaga S;Matsumoto K
通讯作者：
Matsumoto K
影响因子：
3.2
作者：
Kunisaki, Chikara;Akiyama, Hirotoshi;Shimada, Hiroshi
通讯作者：
Shimada, Hiroshi
影响因子：
6.4
作者：
Foschi, Roberto;Lucenteforte, Ersilia;Negri, Eva
通讯作者：
Negri, Eva
影响因子：
11.2
作者：
Kimura, MT;Mori, T;Nagase, H
通讯作者：
Nagase, H