Novel insights into exosomal circular RNAs: Redefining intercellular communication in cancer biology.
Novel insights into exosomal circular RNAs: Redefining intercellular communication in cancer biology.
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DOI：
10.1002/ctm2.636
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发表时间：
2021-12
影响因子：
10.6
通讯作者：
Fan X
中科院分区：
文献类型：
--
作者：
Lin H;Yu J;Gu X;Ge S;Fan X
外泌体是一种特殊类型的膜结合细胞外囊泡，被认为是细胞间信息的理想载体，在局部和系统的细胞间通讯中起着至关重要的作用。近年来的研究表明，环状RNA（circular RNA，circRNA）是非编码RNA家族的成员，在exosomes中含量丰富且稳定。作为癌细胞内或癌细胞与非癌细胞之间细胞间通讯的重要介质，外泌体circRNA参与癌症的多个方面。本文综述了外泌体circRNA的生物起源、性质和功能。特别是，我们描述了它们在肿瘤微环境中的细胞间转移，并将它们的生物学功能与不同的癌症表型联系起来。最后，我们讨论了未来潜在的临床应用。环状RNA（circRNA）可以通过外泌体递送到受体细胞来发挥其功能。外泌体circRNA参与肿瘤微环境中的肿瘤-肿瘤串扰、肿瘤-基质串扰和基质-肿瘤串扰。外泌体circRNA是癌症的有前途的诊断、预后和预测生物标志物，并且外泌体用作递送治疗性circRNA的载体。
Exosomes, a special type of membrane‐bound extracellular vesicle regarded as an ideal carrier for intercellular messages, play an essential role in intercellular communication both locally and systematically. Recent studies have reported that circular RNAs (circRNAs), members of the noncoding RNA family, are abundant and stable in exosomes. As an essential mediator of intercellular communication within cancer cells or between cancer cells and noncancerous cells, exosomal circRNAs participate in multiple aspects of cancer. In this review, we summarize the biogenesis, properties and functions of exosomal circRNAs. In particular, we describe their intercellular transfer in the tumour microenvironment and associate their biological functions with different phenotypes of cancer. Finally, we discuss potential clinical applications in the future. Circular RNAs (circRNAs) can exert their functions via exosome delivery to recipient cells. Exosomal circRNAs are involved in tumour‐to‐tumour crosstalk, tumour‐to‐stroma crosstalk and stroma‐to‐tumour crosstalk in the tumour microenvironment. Exosomal circRNAs are promising diagnostic, prognostic and predictive biomarkers for cancer, and exosomes serve as vehicles to deliver therapeutic circRNAs.
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DOI：
10.1126/science.aau6977
发表时间：
2020-02-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kalluri R;LeBleu VS
通讯作者：
LeBleu VS
DOI：
10.1186/s13058-016-0740-2
发表时间：
2016-08-11
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Bussard KM;Mutkus L;Stumpf K;Gomez-Manzano C;Marini FC
通讯作者：
Marini FC
影响因子：
4.6
作者：
Barrett, Steven P.;Salzman, Julia
通讯作者：
Salzman, Julia
影响因子：
4
作者：
Colombo, Marina;Moita, Catarina;Raposo, Graca
通讯作者：
Raposo, Graca
影响因子：
4.6
作者：
Dou Y;Cha DJ;Franklin JL;Higginbotham JN;Jeppesen DK;Weaver AM;Prasad N;Levy S;Coffey RJ;Patton JG;Zhang B
通讯作者：
Zhang B