Behavioral characterization of acetaldehyde in C57BL/6J mice: locomotor, hypnotic, anxiolytic and amnesic effects
Behavioral characterization of acetaldehyde in C57BL/6J mice: locomotor, hypnotic, anxiolytic and amnesic effects
复制标题
C57BL/6J 小鼠乙醛的行为特征：运动、催眠、抗焦虑和遗忘作用
DOI：
10.1007/s00213-004-1911-x
复制
发表时间：
2004
影响因子：
3.4
通讯作者：
E. Tirelli
中科院分区：
文献类型：
--
作者：
E. Quertemont;Sophie Tambour;Pascale Bernaerts;S. Zimatkin;E. Tirelli
乙醛是乙醇的第一代谢产物，近年来被认为与乙醇的许多行为效应有关，尽管很少有研究直接研究乙醛本身的行为效应。在C57 BL/6 J小鼠中乙醛的抗焦虑样和遗忘作用。（0-300 mg/kg）腹腔注射，研究其对一系列典型行为的影响。在活动箱中测量乙醛的运动效应。翻正反射消失的持续时间被用作乙醛催眠作用的指标。乙醛的抗焦虑作用用高架十字迷宫测试，而遗忘作用用一次性被动回避测试。最后，大脑和血液中的乙醛浓度进行了assessed. Results乙醛诱导显着hypolocomotor效应在170 mg/kg和更高的剂量。此外，在给予170和300 mg/kg乙醛后，翻正反射丧失证明了乙醛的催眠作用。高架十字迷宫表明乙醛不具有抗焦虑样特性。最后，乙醛（100-300 mg/kg）剂量依赖性地改变记忆巩固所示的性能降低的被动回避test.ConclusionsThe目前的结果表明，乙醛诱导镇静，催眠和健忘的影响，而它是没有刺激和抗焦虑的性质在C57 BL/6 J小鼠。然而，在非常高的脑浓度下，腹膜内给药后乙醛的行为影响是明显的。目前的结果还表明，乙醛是不太可能参与在小鼠中的乙醇的抗焦虑特性。
RationaleAcetaldehyde, the first metabolite of ethanol, was recently suggested to contribute to many behavioral effects of ethanol, although few studies have directly investigated the behavioral effects of acetaldehyde itself.ObjectivesThe aim of the present study was to characterize the locomotor, hypnotic, anxiolytic-like and amnesic effects of acetaldehyde in C57BL/6J mice.MethodsIncreasing doses of acetaldehyde (0–300 mg/kg) were injected intraperitoneally and their effects on a series of representative behaviors were investigated. The locomotor effects of acetaldehyde were measured in activity boxes. The duration of the loss of righting reflex was used as an index of the hypnotic effects of acetaldehyde. The anxiolytic-like effects of acetaldehyde were tested with an elevated plus-maze and the amnesic effects with the one-trial passive avoidance test. Finally, brain and blood acetaldehyde concentrations were assessed.ResultsAcetaldehyde induced a significant hypolocomotor effect at 170 mg/kg and higher doses. In addition, the hypnotic effects of acetaldehyde were demonstrated by a loss of righting reflex after the administration of 170 and 300 mg/kg acetaldehyde. The elevated plus-maze showed that acetaldehyde does not possess anxiolytic-like properties. Finally, acetaldehyde (100–300 mg/kg) dose-dependently altered memory consolidation as shown by a reduced performance in the passive avoidance test.ConclusionsThe present results show that acetaldehyde induces sedative, hypnotic and amnesic effects, whereas it is devoid of stimulant and anxiolytic-like properties in C57BL/6J mice. However, the behavioral effects of acetaldehyde after intraperitoneal administration were apparent at very high brain concentrations. The present results also indicate that acetaldehyde is unlikely to be involved in the anxiolytic properties of ethanol in mice.
登录
查看更多内容
DOI：
10.1111/j.1530-0277.2001.tb02306.x
发表时间：
2001-07
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Sergey M. Zimatkin;Anton V. Liopo;V. Satanovskaya;Lubov R. Bardina;R. Deitrich
通讯作者：
Sergey M. Zimatkin;Anton V. Liopo;V. Satanovskaya;Lubov R. Bardina;R. Deitrich
乙醇的激活作用和抑制作用是否会产生耐受性？
DOI：
10.1016/0091-3057(82)90496-8
发表时间：
1982
期刊：
Pharmacology, biochemistry, and behavior
影响因子：
--
作者：
Tabakoff,B;Kiianmaa,K
通讯作者：
Kiianmaa,K
影响因子：
2.3
作者：
Middaugh, LD;Kelley, BM;McGroarty, KK
通讯作者：
McGroarty, KK
通过亚洲人线粒体乙醛脱氢酶基因变异等位基因的纯合性，乙醛的参与可全面防止酒精中毒。
DOI：
--
发表时间：
1999
期刊：
Pharmacogenetics.
影响因子：
--
作者：
Peng,GS;Wang,MF;Chen,CY;Luu,SU;Chou,HC;Li,TK;Yin,SJ
通讯作者：
Yin,SJ