Application of silver nanotriangles as a novel contrast agent in tumor computed tomography imaging
Application of silver nanotriangles as a novel contrast agent in tumor computed tomography imaging
复制标题
银纳米三角形作为新型造影剂在肿瘤CT成像中的应用
DOI：
10.1088/1361-6528/ac21ef
复制
发表时间：
2021-08
期刊：
影响因子：
3.5
通讯作者：
Peidang Liu
中科院分区：
文献类型：
--
作者：
Huiquan Yang;Jing Zhao;Dongdong Li;Yuyu Cao;Fan Li;Jing Ma;Peidang Liu
本研究旨在制备壳聚糖包覆银纳米三角形(AgNTs)，并通过体内外实验评价其CT对比性能。采用籽晶生长法制备了不同尺寸的AgNTs，并用透射电子显微镜、紫外可见吸收光谱和动态光散射对其进行了表征。利用Micro CT对所制备的AgNTs的X射线衰减能力进行了评价。研究了具有最高X射线衰减系数的AgNTs在MDA-MB-231乳腺癌细胞和小鼠乳腺癌模型上的CT对比剂效果。结果表明，所合成的AgNTs均为三角形，平均边长为60~149 nm。在相同活性元素质量浓度下，所有AgNTs均表现出比碘海醇更强的X射线衰减能力，且AgNTs尺寸越大，其X射线衰减系数越大。尺寸最大的AgNTs由于其最强的X射线衰减能力和最好的生物相容性而被选为进一步研究的对象。AgNTs处理的乳腺癌细胞的衰减系数呈浓度依赖性增加。体内CT成像显示，注射AgNTs的肿瘤对比度明显增强。这些结果表明，AgNTs有望成为一种高效的肿瘤CT造影剂。
This study aimed to prepare chitosan-coated silver nanotriangles (AgNTs) and assess their computed tomography (CT) contrast property by in vitro and in vivo experiments. AgNTs with a range of sizes were synthesized by a seed-based growth method, and subsequently characterized by transmission electron microscopy (TEM), ultraviolet–visible absorption spectroscopy and dynamic light scattering. The x-ray attenuation capability of all prepared AgNTs was evaluated using micro CT. The CT contrast effect of AgNTs with the highest x-ray attenuation coefficient was investigated in MDA-MB-231 breast cancer cells and a mouse model of breast cancer. The TEM results displayed that all synthesized AgNTs were triangular in shape and their mean edge lengths ranged from 60 to 149 nm. All AgNTs tested exhibited stronger x-ray attenuation capability than iohexol at the same mass concentration of the active elements, and the larger the AgNTs size, the higher the x-ray attenuation coefficient. AgNTs with the largest size were selected for further research, due to their strongest x-ray attenuation capability and best biocompatibility. The attenuation coefficient of breast cancer cells treated with AgNTs increased in a particle concentration-dependent manner. In vivo CT imaging showed that the contrast of the tumor injected with AgNTs was significantly enhanced. These findings indicated that AgNTs could be a promising candidate for highly efficient tumor CT contrast agents.
登录
查看更多内容
DOI：
10.4103/0974-2700.199523
发表时间：
2017-01
期刊：
Journal of emergencies, trauma, and shock
影响因子：
--
作者：
Caltekin İ;Akyol PY;Topal FE;Karagöz A;Ünlüer EE
通讯作者：
Ünlüer EE
影响因子：
3.5
作者：
C. Scotson;María Muñoz-Hernando;S. Duncan;S. Ruiz;S. Keyes;A. van Veelen;I. Dunlop;T. Roose
通讯作者：
C. Scotson;María Muñoz-Hernando;S. Duncan;S. Ruiz;S. Keyes;A. van Veelen;I. Dunlop;T. Roose
影响因子：
19
作者：
Aherne, Damian;Ledwith, Deirdre M.;Kelly, John M.
通讯作者：
Kelly, John M.
影响因子：
--
作者：
Potara, Monica;Gabudean, Ana-Maria;Astilean, Simion
通讯作者：
Astilean, Simion
影响因子：
9.7
作者：
Boca, Sanda C.;Potara, Monica;Astilean, Simion
通讯作者：
Astilean, Simion