Sleep disorders in people with type 2 diabetes and associated health outcomes: a review of the literature.
Sleep disorders in people with type 2 diabetes and associated health outcomes: a review of the literature.
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患有2型糖尿病和相关健康结果的患者的睡眠障碍：文献综述。
DOI：
10.1007/s00125-021-05541-0
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发表时间：
2021-11
期刊：
影响因子：
8.2
通讯作者：
Rutters F
中科院分区：
文献类型：
--
作者：
Schipper SBJ;Van Veen MM;Elders PJM;van Straten A;Van Der Werf YD;Knutson KL;Rutters F
睡眠障碍与2型糖尿病的发展有关，并增加糖尿病并发症的风险。因此，治疗睡眠障碍可能在预防糖尿病进展方面发挥重要作用。然而，睡眠障碍的检测和治疗并不是2型糖尿病患者标准化护理的一部分。为了强调睡眠障碍在2型糖尿病患者中的重要性，我们对有关2型糖尿病睡眠障碍患病率以及睡眠障碍与健康结果（例如血糖控制、微血管和大血管）之间的关联的文献进行了综述。并发症、抑郁症、死亡率和生活质量。此外，我们还研究了治疗2型糖尿病患者的睡眠障碍在多大程度上改善了这些健康结果。我们在PubMed中进行了从成立到2021年1月的文献检索，使用睡眠障碍，2型糖尿病，患病率，治疗和健康结果的检索词。观察性和实验性研究都包括在综述中。我们发现，与普通人群相比，失眠（39% [95%CI 34，44]），阻塞性睡眠呼吸暂停（55-86%）和不宁腿综合征（8-45%）在2型糖尿病患者中更普遍。没有研究报告昼夜节律睡眠-觉醒障碍、中枢性嗜睡症或异眠症的患病率。此外，一些横断面和前瞻性研究表明，睡眠障碍对至少一个糖尿病领域的健康结果产生负面影响，特别是血糖控制。例如，失眠与HbA 1c水平升高相关（2.51 mmol/mol [95% CI 1.1，4.4]; 0.23% [95% CI 0.1，0.4]）。最后，调查2型糖尿病患者睡眠障碍治疗效果的随机对照试验很少，基于少数参与者，有时不确定。减肥、睡眠教育和认知行为疗法等传统疗法似乎能有效改善2型糖尿病患者的睡眠和健康状况。我们的结论是，睡眠障碍在2型糖尿病患者中非常普遍，对健康结果产生负面影响。由于睡眠障碍的治疗可以预防糖尿病的进展，因此应努力诊断和治疗2型糖尿病的睡眠障碍，以最终改善健康状况，从而提高生活质量。 在线版本包含同行评审但未经编辑的补充材料，包括可供下载的数字幻灯片，可在10.1007/s 00125 -021-05541-0获得。
Sleep disorders are linked to development of type 2 diabetes and increase the risk of developing diabetes complications. Treating sleep disorders might therefore play an important role in the prevention of diabetes progression. However, the detection and treatment of sleep disorders are not part of standardised care for people with type 2 diabetes. To highlight the importance of sleep disorders in people with type 2 diabetes, we provide a review of the literature on the prevalence of sleep disorders in type 2 diabetes and the association between sleep disorders and health outcomes, such as glycaemic control, microvascular and macrovascular complications, depression, mortality and quality of life. Additionally, we examine the extent to which treating sleep disorders in people with type 2 diabetes improves these health outcomes. We performed a literature search in PubMed from inception until January 2021, using search terms for sleep disorders, type 2 diabetes, prevalence, treatment and health outcomes. Both observational and experimental studies were included in the review. We found that insomnia (39% [95% CI 34, 44]), obstructive sleep apnoea (55–86%) and restless legs syndrome (8–45%) were more prevalent in people with type 2 diabetes, compared with the general population. No studies reported prevalence rates for circadian rhythm sleep–wake disorders, central disorders of hypersomnolence or parasomnias. Additionally, several cross-sectional and prospective studies showed that sleep disorders negatively affect health outcomes in at least one diabetes domain, especially glycaemic control. For example, insomnia is associated with increased HbA1c levels (2.51 mmol/mol [95% CI 1.1, 4.4]; 0.23% [95% CI 0.1, 0.4]). Finally, randomised controlled trials that investigate the effect of treating sleep disorders in people with type 2 diabetes are scarce, based on a small number of participants and sometimes inconclusive. Conventional therapies such as weight loss, sleep education and cognitive behavioural therapy seem to be effective in improving sleep and health outcomes in people with type 2 diabetes. We conclude that sleep disorders are highly prevalent in people with type 2 diabetes, negatively affecting health outcomes. Since treatment of the sleep disorder could prevent diabetes progression, efforts should be made to diagnose and treat sleep disorders in type 2 diabetes in order to ultimately improve health and therefore quality of life. The online version contains peer-reviewed but unedited supplementary material including a slideset of the figures for download, available at 10.1007/s00125-021-05541-0.
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影响因子：
16.2
作者：
Grimaldi D;Beccuti G;Touma C;Van Cauter E;Mokhlesi B
通讯作者：
Mokhlesi B
DOI：
10.2147/dmso.s23904
发表时间：
2011
期刊：
Diabetes, metabolic syndrome and obesity : targets and therapy
影响因子：
--
作者：
Garfinkel D;Zorin M;Wainstein J;Matas Z;Laudon M;Zisapel N
通讯作者：
Zisapel N
影响因子：
2.2
作者：
Gabric K;Matetic A;Vilovic M;Ticinovic Kurir T;Rusic D;Galic T;Jonjic I;Bozic J
通讯作者：
Bozic J
影响因子：
6.3
作者：
Jorgensen, Jeanette Therming;Karlsen, Sashia;Andersen, Zorana Jovanovic
通讯作者：
Andersen, Zorana Jovanovic
影响因子：
5.6
作者：
Blom, Kerstin;Jernelov, Susanna;Kaldo, Viktor
通讯作者：
Kaldo, Viktor