Anti-tumor effects of cavitation induced with phase-change nano droplet and ultrasound
Anti-tumor effects of cavitation induced with phase-change nano droplet and ultrasound
复制标题
相变纳米液滴和超声诱导空化的抗肿瘤作用
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
S. Umemura
中科院分区：
文献类型：
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作者：
K. Kawabata;R. Asami;T. Azuma;H. Yoshikawa;S. Umemura
我们进行了一项研究，以探讨一种新的诊断和治疗剂，相变纳米液滴（PCND）的治疗应用，结合1 MHz的超声。使用凝胶体模发现，仅当预先暴露使PCND的相从液体变为气体的超声（相变超声）时，PCND才作为1-MHz超声的空化加速器工作。不能将其相改变为气体的纳米液滴即使在相变超声的存在下也不工作。借助于PCND的空化诱导通过B型回波描记术作为亮度变化可观察到。在PCND和相变超声存在下，在肿瘤裸小鼠的体内实验中也观察到这种亮度变化。此外，在亮度变化的部位观察到组织损伤。缺乏PCND或相变超声不会引起任何亮度变化，这表明与凝胶体模在活组织中工作的机制相同。我们的研究结果是有希望的，在一个高贵的超声治疗系统具有高选择性和安全性，同时提高目前的超声肿瘤治疗系统的吞吐量。
We performed a study to look into the therapeutic application of a novel diagnostic and therapeutic agent, phase change nano droplet (PCND), in combination with 1-MHz ultrasound. It was found using gel phantoms that PCND works as a cavitation accelerator for a 1-MHz ultrasound only when an ultrasound which changes the phase of PCND from liquid to gas (phase change ultrasound) is exposed in advance. A nano droplet that cannot change its phase to a gas does not work even in the presence of the phase change ultrasound. The cavitation induction with the aid of a PCND was observable by B-mode echography as a brightness change. Such a brightness change was also observed in in vivo experiments on tumor baring mice in the presence of a PCND and a phase change ultrasound. Moreover, tissue damage was observed at the site of the brightness change. The lack of either a PCND or a phase change ultrasound did not induce any brightness change, suggesting the same mechanism as a gel phantom works in living tissues. Our results are promising for use in a noble ultrasound therapy system with high selectivity and safety while improving the throughput of current ultrasound tumor treatment systems.
影响因子：
2.9
作者：
Kripfgans, OD;Fowlkes, JB;Carson, PL
通讯作者：
Carson, PL