Detection of P-glycoprotein in squamous cell carcinomas of the head and neck.
Detection of P-glycoprotein in squamous cell carcinomas of the head and neck.
复制标题
头颈部鳞状细胞癌中 P-糖蛋白的检测。
DOI：
10.1001/archotol.1993.01880160057009
复制
发表时间：
1993
期刊：
影响因子：
--
通讯作者：
J. Gluckman
中科院分区：
文献类型：
--
作者：
D. Kelley;Z. Pavelic;M. Gapany;P. Stambrook;L. Pavelic;S. Gapany;J. Gluckman
多药耐药的一个既定机制是P-糖蛋白表达升高。使用新开发的单克隆抗体UIC 2，它是特异性的人MDR 1基因产物和识别的蛋白质的外部表位的P-糖蛋白的表达，通过免疫组化检查在鳞状细胞癌的头部和颈部。在60%的样本中检测到P-糖蛋白。在接受MDR 1依赖性药物的8例患者中，将MDR 1表达与化疗的临床反应进行比较，8例患者中有7例（89%）的反应被准确预测。P-糖蛋白阳性表达与肿瘤分化程度有关，与其他临床因素无关。因此，分析P-糖蛋白的表达可能在计划头颈癌患者的化疗方案时发挥作用，并且可能是这些患者的额外预后和诊断工具。
One established mechanism of multidrug resistance is elevated expression of P-glycoprotein. The expression of P-glycoprotein by immunohistochemistry was examined in squamous cell carcinomas of the head and neck using a newly developed monoclonal antibody, UIC2, which is specific to the human MDR1 gene product and recognizes an external epitope of the protein. P-glycoprotein was detected in 60% of the samples. MDR1 expression was compared with clinical response to chemotherapy in eight patients who received MDR1-dependent drugs and response was accurately predicted in seven (89%) of eight patients. Positive P-glycoprotein staining correlated with the degree of tumor differentiation, but not with other clinical factors. Therefore, analyzing the expression of P-glycoprotein may play a role when planning chemotherapeutic regimens for patients with head and neck cancer and may be an additional prognostic and diagnostic tool in these patients.
登录
查看更多内容
影响因子：
45.3
作者：
CHAN, HSL;THORNER, PS;LING, V
通讯作者：
LING, V
影响因子：
2.6
作者：
Mahmoudi S;Yaghmaei B;Sharifzadeh Ekbatani M;Pourakbari B;Navaeian A;Parvaneh N;Haghi Ashtiani MT;Mamishi S
通讯作者：
Mamishi S
DOI：
10.1073/pnas.87.18.7160
发表时间：
1990-09-01
影响因子：
11.1
作者：
NOONAN, KE;BECK, C;RONINSON, IB
通讯作者：
RONINSON, IB
影响因子：
3.2
作者：
CORDONCARDO, C;OBRIEN, JP;MELAMED, MR
通讯作者：
MELAMED, MR
哺乳动物细胞中与多药耐药性相关的基因的扩增和表达。
DOI：
10.1126/science.2421411
发表时间：
1986
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Scotto,KW;Biedler,JL;Melera,PW
通讯作者：
Melera,PW