Sonodelivery in Skeletal Muscle: Current Approaches and Future Potential.
Sonodelivery in Skeletal Muscle: Current Approaches and Future Potential.
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DOI：
10.3390/bioengineering7030107
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发表时间：
2020-09-09
期刊：
影响因子：
--
通讯作者：
Figueiredo ML
中科院分区：
文献类型：
--
作者：
Decker RE;Lamantia ZE;Emrick TS;Figueiredo ML
There are currently multiple approaches to facilitate gene therapy via intramuscular gene delivery, such as electroporation, viral delivery, or direct DNA injection with or without polymeric carriers. Each of these methods has benefits, but each method also has shortcomings preventing it from being established as the ideal technique. A promising method, ultrasound-mediated gene delivery (or sonodelivery) is inexpensive, widely available, reusable, minimally invasive, and safe. Hurdles to utilizing sonodelivery include choosing from a large variety of conditions, which are often dependent on the equipment and/or research group, and moderate transfection efficiencies when compared to some other gene delivery methods. In this review, we provide a comprehensive look at the breadth of sonodelivery techniques for intramuscular gene delivery and suggest future directions for this continuously evolving field.
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