Unique underlying principles shaping copper homeostasis networks.
Unique underlying principles shaping copper homeostasis networks.
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DOI：
10.1007/s00775-022-01947-2
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发表时间：
2022-09
影响因子：
3
通讯作者：
Arguello, Jose M.
中科院分区：
文献类型：
--
作者：
Novoa-Aponte, Lorena;Arguello, Jose M.
铜在细胞中作为关键氧化还原酶的辅因子是必不可少的。细菌已经获得了分子成分，这些分子成分可以感知、吸收、分配和排出铜，从而确保铜酶被金属化并维持稳态金属水平。为了防止有害反应，蛋白质以高亲和力与铜离子结合，并通过配体交换转移金属，从而保证铜离子总是络合的。因此，铜在细胞隔室内和跨细胞膜的定向分布需要同源holo-apo蛋白伴侣之间的特定动态相互作用和金属交换。这些金属交换反应由热力学和动力学参数决定，并受质量作用的影响。然后，铜分布可以被概念化为维持生理铜稳态的单一相互作用元件的分子系统。本文综述了铜高亲和力结合和交换反应对稳态机制的影响，描述细胞作为稳态系统的概念模型，有助于铜稳态的各种分子功能，以及负责模型细菌中铜稳态的替代系统架构。
Copper is essential in cells as a cofactor for key redox enzymes. Bacteria have acquired molecular components that sense, uptake, distribute, and expel copper ensuring that cuproenzymes are metallated and steady-state metal levels are maintained. Toward preventing deleterious reactions, proteins bind copper ions with high affinities and transfer the metal via ligand exchange, warranting that copper ions are always complexed. Consequently, the directional copper distribution within cell compartments and across cell membranes requires specific dynamic interactions and metal exchange between cognate holo-apo protein partners. These metal exchange reactions are determined by thermodynamic and kinetics parameters and influenced by mass action. Then, copper distribution can be conceptualized as a molecular system of singular interacting elements that maintain a physiological copper homeostasis. This review focuses on the impact of copper high-affinity binding and exchange reactions on the homeostatic mechanisms, the conceptual models to describe the cell as a homeostatic system, the various molecule functions that contribute to copper homeostasis, and the alternative system architectures responsible for copper homeostasis in model bacteria.
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影响因子：
15
作者：
Bagchi P;Morgan MT;Bacsa J;Fahrni CJ
通讯作者：
Fahrni CJ
影响因子：
3.6
作者：
BROWN, NL;BARRETT, SR;ROUCH, DA
通讯作者：
ROUCH, DA
影响因子：
5.2
作者：
Antoine, Rudy;Rivera-Millot, Alex;Jacob-Dubuisson, Francoise
通讯作者：
Jacob-Dubuisson, Francoise
感染过程中铜的阴阳和阳。
DOI：
10.1007/s00775-016-1335-1
发表时间：
2016-04
期刊：
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
影响因子：
--
作者：
Besold AN;Culbertson EM;Culotta VC
通讯作者：
Culotta VC
影响因子：
4.3
作者：
Lohmeyer, Eva;Schroeder, Sebastian;Pawlik, Grzegorz;Trasnea, Petru-Iulian;Peters, Annette;Daldal, Fevzi;Koch, Hans-Georg
通讯作者：
Koch, Hans-Georg