The relationship between the genetic and environmental influences on common internalizing psychiatric disorders and mental well-being.
The relationship between the genetic and environmental influences on common internalizing psychiatric disorders and mental well-being.
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DOI：
10.1007/s10519-011-9466-1
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发表时间：
2011-09
影响因子：
2.6
通讯作者：
Keyes, Corey L. M.
中科院分区：
文献类型：
--
作者：
Kendler, Kenneth S.;Myers, John M.;Maes, Hermine H.;Keyes, Corey L. M.
为了确定常见内化精神病理学 (IP) 和心理健康 (MWB) 的遗传和环境风险因素之间的关系，我们对来自 1995 年和 2005 年 MIDUS 全国样本的 1,386 名同性双胞胎的情绪、社会和心理健康状况以及去年的重度抑郁症 (MD)、广泛性焦虑症 (GAD) 和惊恐发作病史进行了详细测量。 使用 Mx 程序进行统计分析。在 1995 年的数据中，最佳拟合模型包含 MD、GAD 和惊恐发作的一个显着遗传的公因子，以及这三种幸福感指标的一个强遗传的公因子。 IP 的遗传和环境风险因素分别占 MWB 遗传和环境影响的 50% 和 5%。然后，我们使用 1995 年和 2005 年的数据构建了两个常见因素，反映了对 (i) MD 和 GAD 以及 (ii) 情绪和心理健康的暂时稳定影响。 IP 稳定责任的遗传和环境风险因素分别占 MWB 稳定遗传和环境影响的 41% 和 29%。这项研究表明，IP 的遗传风险因素占 MWB 遗传影响的 41-50%。环境风险因素的重叠程度较小。虽然IP平均水平较低反映了MWB的高遗传倾向，但其他独立的遗传影响在产生良好的心理健康方面发挥着重要作用。
To determine the relationship between the genetic and environmental risk factors for common internalizing psychopathology (IP) and mental well-being (MWB), we examined detailed measures of emotional, social and psychological well-being, and a history of major depression (MD), generalized anxiety disorder (GAD) and panic attacks in the last year, in 1,386 twins from same-sex pairs from the MIDUS national USA sample assessed in 1995 and then again in 2005. Statistical analyses were performed with the Mx program. In the 1995 data, the best fit model contained one substantially heritable common factor for MD, GAD and panic attacks, and one strongly heritable common factor for the three well-being measures. Genetic and environmental risk factors for IP accounted for, respectively, 50 and 5%, of the genetic and environmental influences on MWB. We then constructed, using 1995 and 2005 data, two common factors that reflected temporally stable influences on (i) MD and GAD, and (ii) on emotional and psychological well-being. Genetic and environmental risk factors for the stable liability to IP accounted for 41 and 29% of the stable genetic and environmental influences, respectively, on MWB. This study suggests that genetic risk factors for IP make up 41–50% of the genetic influences on MWB. The overlap of environmental risk factors is more modest. Although low levels of IP on average reflect a high genetic propensity for MWB, other independent genetic influences play an important role in producing good mental health.
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影响因子：
16.4
作者：
Keyes, Corey L. M.
通讯作者：
Keyes, Corey L. M.
影响因子：
2.6
作者：
NEALE, MC;EAVES, LJ;KENDLER, KS
通讯作者：
KENDLER, KS
影响因子：
12.7
作者：
Keyes, Corey L. M.;Myers, John M.;Kendler, Kenneth S.
通讯作者：
Kendler, Kenneth S.
影响因子：
7.6
作者：
Roysamb, E;Tambs, K;Harris, JR
通讯作者：
Harris, JR
影响因子：
--
作者：
Kendler, KS;Prescott, CA;Neale, MC
通讯作者：
Neale, MC