Midline crossing and Slit responsiveness of commissural axons require USP33.

Midline crossing and Slit responsiveness of commissural axons require USP33.
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DOI:
10.1038/nn.2382
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发表时间:
2009-09
影响因子:
25
通讯作者:
Wu JY
Wu JY
中科院分区:
医学1区
文献类型:
--
作者:
Yuasa-Kawada J;Kinoshita-Kawada M;Wu G;Rao Y;Wu JY

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Commissural axons cross the ventral midline of the neural tube in a Slit-dependent manner. The underlying molecular mechanisms remain to be elucidated. Here we report that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor. USP33 is essential for midline crossing by commissural axons and for their response to Slit. Our results reveal a previously unknown role of USP33 in vertebrate commissural axon guidance and in Slit signaling.
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