Levels of circulating endothelial cells and colony forming units are influenced by age and dyslipidaemia
Levels of circulating endothelial cells and colony forming units are influenced by age and dyslipidaemia
复制标题
循环内皮细胞和集落形成单位的水平受年龄和血脂异常的影响
作者：
Francesca I. Fabbri;Lindsey Clarke;Guosu Wang;M. Charakida;E. Ellins;Neil Halliday;P. Brogan;J. Deanfield;J. Halcox;N. Klein
背景：儿童时期内皮损伤和修复之间的平衡知之甚少。我们研究了健康儿童、成人和家族性高胆固醇血症(FH)儿童的这种关系。方法：循环内皮细胞(CEC)作为血管损伤的标志，通过计数集落形成单位(CFU)来评估血管修复。结果：CEC数量随着年龄的增加而增加。与健康儿童相比，FH儿童CEC水平升高，其数值与健康成年人相似。健康儿童的CFU数高于健康成人或FH儿童。即使在调整了混杂的危险变量后，内皮依赖的血管功能，通过血流介导的扩张测量，也与CFU数量呈正相关。结论：CEC水平随着年龄的增长而增加，CFU水平随着年龄的增长而减少。在儿童时期，在临床可检测到的心血管功能障碍出现之前，具有动脉粥样硬化性疾病主要危险因素的儿童的这些血管损伤和修复指标的水平接近成人。
Background:The balance between endothelial injury and repair in childhood is poorly understood. We examined this relationship in healthy children, in adults, and in children with familial hypercholesterolemia (FH).Methods:Circulating endothelial cells (CECs) were measured as a marker of vascular injury, with vascular repair assessed by counting colony-forming units (CFUs), also known as endothelial progenitor cells.Results:CEC number increased with age. Children with FH had elevated CECs as compared with healthy children, with similar levels numerically to those found in healthy adults. CFU numbers were higher in healthy children than either healthy adults or children with FH. Endothelium-dependent vascular function, measured by flow-mediated dilatations, was positively associated with CFU number, even after adjustment for confounding risk variables.Conclusion:Levels of CECs increase and CFUs decrease with age. In childhood, before the onset of clinically detectable cardiovascular dysfunction, children with a major risk factor for atherosclerotic disease have levels of these indexes of vascular injury and repair approaching those seen in adults.
影响因子：
2.8
作者：
Hoetzer, Greta L.;MacEneaney, Owen J.;DeSouza, Christopher A.
通讯作者：
DeSouza, Christopher A.
影响因子：
20.3
作者：
Yoder, Mervin C.;Mead, Laura E.;Ingram, David A.
通讯作者：
Ingram, David A.
评估内皮祖细胞的身份、表型和命运。
DOI：
10.1161/atvbaha.107.155960
发表时间：
2008-09
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Hirschi KK;Ingram DA;Yoder MC
通讯作者：
Yoder MC