The effects of anaemia on heart, placenta and body weight, and blood pressure in fetal and neonatal rats.
The effects of anaemia on heart, placenta and body weight, and blood pressure in fetal and neonatal rats.
复制标题
贫血对胎儿和新生大鼠的心脏、胎盘和体重以及血压的影响。
DOI：
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Mark A. Hanson
中科院分区：
文献类型：
--
作者：
C. Crowe;P. Dandekar;M. Fox;K. Dhingra;Laura Bennet;Mark A. Hanson
1.报告说，孕产妇贫血在怀孕期间与更大的胎盘：出生体重比，这倾向于对高出生后血压的人，导致我们检查的影响，孕产妇贫血在怀孕期间对胎盘的大小，胎儿和新生儿的生长，和血压的发展在大鼠。2.在交配前诱导雌性大鼠营养性贫血，并在整个妊娠期和直至幼仔断奶期间维持。在妊娠第20天（E20）研究胎仔。在出生后第20天（P20）和第40天（P40）对幼崽进行研究，在第21天断奶后进食正常大鼠饲料。3.在贫血组胎盘：胎儿体重比低于对照组。贫血组所有年龄段的体重均低于对照组，尽管贫血组在P20和P40之间的生长速度更快。4.在P20时，贫血组的心脏重量几乎是对照组的两倍，这表明他们的心血管发育发生了变化。然而，矛盾的是，贫血组的收缩压低于对照组。5.到P40时，贫血组的收缩压（136 +/-3 mmHg）升高，且高于对照组幼仔（126 +/-3 mmHg）。6.总之，我们已经表明，有一个显着的产后收缩压升高与母亲贫血在怀孕期间，这是不相关的更大的胎盘：出生体重比。在断奶前，贫血的幼崽比对照组有较低的收缩压，出生后生长速度和血压之间有重要的联系。
1. Reports that maternal anaemia in pregnancy is associated with a greater placental: birth weight ratio, which predisposes towards high postnatal blood pressure in the human, led us to examine the effects of maternal anaemia during pregnancy on placental size, fetal and neonatal growth, and blood pressure development in the rat. 2. Nutritional anaemia was induced in female rats prior to mating and maintained throughout pregnancy and up until weaning of the pups. Fetuses were studied at 20 days of gestation (E20). Pups were studied on postnatal days 20 (P20) and 40 (P40), having been weaned onto normal rat chow at 21 days. 3. In the anaemic group placental: fetal body weight ratios were lower compared with controls. Body weights at all ages were lower in the anaemic group than in controls, despite a greater rate of growth in the anaemic group between P20 and P40. 4. At P20 heart weights of the anaemic group were almost twice that of controls, suggesting an alteration in their cardiovascular development. However, paradoxically, the systolic blood pressure of the anaemic group was lower than that of controls. 5. By P40 the systolic blood pressure of the anaemic group (136 +/‐ 3 mmHg) had increased and was greater than that in control pups (126 +/‐ 3 mmHg). 6. In conclusion, we have shown that there is a pronounced postnatal rise in systolic blood pressure associated with maternal anaemia during pregnancy, which is not related to a greater placental: birth weight ratio. Before weaning, anaemic pups have a lower systolic blood pressure than controls and there is an important association between the rate of postnatal growth and blood pressure.
遗传性高血压和营养性贫血对大鼠心室重构和心肌损伤的影响。
影响因子：
10.8
作者：
Olivetti,G;Quaini,F;Lagrasta,C;Ricci,R;Tosini,P;Capasso,JM;Anversa,P
通讯作者：
Anversa,P
近交系大鼠生长与血压的关系。
DOI：
10.1152/ajpregu.1994.266.3.r702
发表时间：
1994
期刊：
The American journal of physiology
影响因子：
--
作者：
Schork,NJ;Jokelainen,P;Grant,EJ;Schork,MA;Weder,AB
通讯作者：
Weder,AB