Evidence of discontinuity between psychosis-risk and non-clinical samples in the neuroanatomical correlates of social function.
Evidence of discontinuity between psychosis-risk and non-clinical samples in the neuroanatomical correlates of social function.
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DOI：
10.1016/j.scog.2022.100252
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发表时间：
2022-09
期刊：
影响因子：
--
通讯作者：
Frangou S
中科院分区：
文献类型：
--
作者：
Haas SS;Doucet GE;Antoniades M;Modabbernia A;Corcoran CM;Kahn RS;Kambeitz J;Kambeitz-Ilankovic L;Borgwardt S;Brambilla P;Upthegrove R;Wood SJ;Salokangas RKR;Hietala J;Meisenzahl E;Koutsouleris N;Frangou S
社会功能障碍是精神病临床高危状态的一个主要特征。先前的研究已经确定了与慢性阻塞性肺疾病患者社会功能结果受损相关的神经解剖学模式。目前这项研究的目的是测试CHR-P的社会功能障碍是在神经生物学上是不同的，还是在社会功能个体差异的正态分布的下端是连续的。我们使用机器学习分类器测试了来自两个非临床样本(总计n=1763)的个体的神经成像图谱中是否存在先前验证的大脑结构模式，该模式与CHR-P(CHR-结果-神经签名)中受损的社会结果相关，并检查了其与社会功能、精神病理学和认知的关系。尽管可以在非临床样本的子集中检测到CRR-结局-神经特征，但它与不良社会结局或较高的精神病理水平无关。然而，神经解剖学特征与CRR-结果-神经特征高度一致的参与者在液体(PFDR=0.004)和结晶智力(PFDR=0.01)、认知灵活性(PFDR=0.02)、抑制控制(PFDR=0.01)、工作记忆(PFDR=0.0005)和处理速度(PFDR=0.04)方面表现出微妙的劣势。我们提供的证据表明，当应用于非临床样本时，来自精神病风险丰富人群的社会功能障碍的大脑结构基础存在分歧。这种方法在通过比较患者群体和具有相同神经解剖学特征的非临床样本来识别与精神病有关的大脑机制方面似乎很有希望。在非临床样本中可以检测到CHR-P状态下不良社会结局的神经特征。这一神经特征在非临床样本中预测了细微的认知缺陷。CHR-P来源的神经标志物的预测价值可能不适用于非临床样本。
Social dysfunction is a major feature of clinical-high-risk states for psychosis (CHR-P). Prior research has identified a neuroanatomical pattern associated with impaired social function outcome in CHR-P. The aim of the current study was to test whether social dysfunction in CHR-P is neurobiologically distinct or in a continuum with the lower end of the normal distribution of individual differences in social functioning. We used a machine learning classifier to test for the presence of a previously validated brain structural pattern associated with impaired social outcome in CHR-P (CHR-outcome-neurosignature) in the neuroimaging profiles of individuals from two non-clinical samples (total n = 1763) and examined its association with social function, psychopathology and cognition. Although the CHR-outcome-neurosignature could be detected in a subset of the non-clinical samples, it was not associated was adverse social outcomes or higher psychopathology levels. However, participants whose neuroanatomical profiles were highly aligned with the CHR-outcome-neurosignature manifested subtle disadvantage in fluid (PFDR = 0.004) and crystallized intelligence (PFDR = 0.01), cognitive flexibility (PFDR = 0.02), inhibitory control (PFDR = 0.01), working memory (PFDR = 0.0005), and processing speed (PFDR = 0.04). We provide evidence of divergence in brain structural underpinnings of social dysfunction derived from a psychosis-risk enriched population when applied to non-clinical samples. This approach appears promising in identifying brain mechanisms bound to psychosis through comparisons of patient populations to non-clinical samples with the same neuroanatomical profiles. A neurosignature of poor social outcome in CHR-P states was detectable in non-clinical samples. This neurosignature predicted subtle cognitive disadvantage in non-clinical sample. The predictive value of CHR-P derived neurosignatures may not generalize to non-clinical samples.
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DOI：
10.1523/jneurosci.1929-08.2008
发表时间：
2008-09-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bassett DS;Bullmore E;Verchinski BA;Mattay VS;Weinberger DR;Meyer-Lindenberg A
通讯作者：
Meyer-Lindenberg A
影响因子：
4.5
作者：
Bolt, Luke K.;Amminger, G. Paul;Allott, Kelly A.
通讯作者：
Allott, Kelly A.
影响因子：
25.8
作者：
Catalan, Ana;Salazar de Pablo, Gonzalo;Fusar-Poli, Paolo
通讯作者：
Fusar-Poli, Paolo
精神病高风险状态：全面的最新评论。
影响因子：
25.8
作者：
Fusar-Poli, Paolo;Borgwardt, Stefan;Bechdolf, Andreas;Addington, Jean;Riecher-Rossler, Anita;Schultze-Lutter, Frauke;Keshavan, Matcheri;Wood, Stephen;Ruhrmann, Stephan;Seidman, Larry J.;Valmaggia, Lucia;Cannon, Tyrone;Velthorst, Eva;De Haan, Lieuwe;Cornblatt, Barbara;Bonoldi, Ilaria;Birchwood, Max;McGlashan, Thomas;Carpenter, William;McGorry, Patrick;Klosterkotter, Joachim;McGuire, Philip;Yung, Alison
通讯作者：
Yung, Alison
影响因子：
25.8
作者：
Koutsouleris, Nikolaos;Kambeitz-Ilankovic, Lana;Borgwardt, Stefan
通讯作者：
Borgwardt, Stefan