Effect of perioperative intravenous lidocaine on postoperative outcomes in patients undergoing resection of colorectal cancer: a protocol for systematic review and meta-analysis.
Effect of perioperative intravenous lidocaine on postoperative outcomes in patients undergoing resection of colorectal cancer: a protocol for systematic review and meta-analysis.
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DOI：
10.1136/bmjopen-2021-048803
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发表时间：
2021-08-23
期刊：
影响因子：
2.9
通讯作者：
Bo L
中科院分区：
文献类型：
--
作者：
Ji W;Zhang X;Sun G;Wang X;Liu J;Bian J;Bo L
使用局部麻醉剂的技术提供了高质量的止痛，而这些药物的抗炎特性可能是一个额外的优势。围术期静脉注射利多卡因不仅对术后疼痛有积极的效果，而且由于其镇痛、抗炎和阿片类药物的节省作用，还可以改善肠功能，延长住院时间。然而，在接受结直肠癌切除术的患者中，这些潜在的好处还没有得到很好的证实。本研究旨在确定围手术期静脉注射利多卡因对结直肠癌切除术后患者预后的影响。PubMed、Embase、Web of Science、CNKI、SinoMed和Wanfang数据库被电子检索，以包括比较2021年8月之前接受结直肠癌切除术的患者围手术期静脉注射利多卡因和安慰剂的随机对照试验。还将搜索临床试验登记、潜在的灰色文献和会议摘要。两名审查员将筛选文献，提取数据，并评估独立纳入的研究的偏倚风险。主要的结果变量将是长期生存结果、肿瘤复发和转移率以及肠道功能的恢复。次要结果变量将包括术后4、12、24和48小时的疼痛严重程度、术后恶心和呕吐的发生率以及住院时间。将使用Cochrane Collaboration和Stata V.12.0提供的Revman V.5.4软件进行荟萃分析。将进行分组和敏感性分析。由于用于这项系统性审查的数据将完全从已发表的研究中提取，因此不需要患者的伦理批准和知情同意。这项系统的评估将发表在同行评议的期刊上，在会议上提交，并在社交媒体平台上分享。CRD42020216232。
Techniques using local anaesthetics provide high-quality analgesia, while the anti-inflammatory properties of these drugs may represent an additional advantage. Perioperative intravenous lidocaine has shown positive effects not only on postoperative pain but also on bowel function and duration of hospital stay, due to its analgesic, anti-inflammatory and opioid-sparing effects. However, these potential benefits are not well established in patients undergoing resection with colorectal cancer. This research aims to determine the effect of perioperative intravenous lidocaine on postoperative outcomes in patients undergoing resection of colorectal cancer. PubMed, Embase, Web of Science, CNKI, SinoMed and WanFang Data databases were electronically retrieved to include the randomised controlled trials comparing perioperative intravenous lidocaine with placebo infusion in patients undergoing resection of colorectal cancer before August 2021. Registers of clinical trials, potential grey literature and abstracts from conferences will also be searched. Two reviewers will screen literature, extract data and assess risk of bias of studies included independently. The primary outcome variable will be long-term survival outcome, tumour recurrence and metastasis rate, and restoration of intestinal function. The secondary outcome variables will consist of the severity of postoperative pain at 4, 12, 24 and 48 hours after surgery, the incidence of postoperative nausea and vomiting, and the length of hospital stay. A meta-analysis will be performed using RevMan V.5.4 software provided by the Cochrane Collaboration and Stata V.12.0. subgroup and sensitivity analyses will be conducted. Because the data used for this systematic review will be exclusively extracted from published studies, ethical approval and informed consent of patients will not be required. The systematic review will be published in a peer-reviewed journal, presented at conferences and shared on social media platforms. CRD42020216232.
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影响因子：
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作者：
Hozo SP;Djulbegovic B;Hozo I
通讯作者：
Hozo I
影响因子：
1.6
作者：
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DOI：
10.5662/wjm.v5.i4.238
发表时间：
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期刊：
World journal of methodology
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Hanisch, Ernst
全身给予利多卡因可减少异丙酚-瑞芬太尼麻醉后接受胸外科手术患者的吗啡需求和术后疼痛
影响因子：
3.6
作者：
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通讯作者：
Li, Junfa
DOI：
10.1007/s00464-009-0652-7
发表时间：
2010-03-01
影响因子：
3.1
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Techner, Lee