Stem cells as drug delivery methods: application of stem cell secretome for regeneration.
Stem cells as drug delivery methods: application of stem cell secretome for regeneration.
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DOI：
10.1016/j.addr.2014.10.007
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发表时间：
2015-03
影响因子：
16.1
通讯作者：
Damaser, Margot S.
中科院分区：
文献类型：
--
作者：
Tran, Christine;Damaser, Margot S.
关键词：
间充质干细胞 (MSC) 是一种独特的细胞群，其具有无限自我更新、分化为多个细胞谱系和形成克隆细胞群的能力。最初人们认为这种广泛的可塑性能力决定了间充质干细胞的治疗潜力。然而，最近越来越多的文献让人们越来越认识到干细胞产生的一系列引人注目的生物活性分子。这种蛋白质环境或“分泌组”包含多种细胞因子、趋化因子、血管生成因子和生长因子。人们越来越认识到这些分子的自分泌/旁分泌作用是调节许多生理过程的关键，包括引导内源细胞和祖细胞到达损伤部位以及介导细胞凋亡、疤痕形成和组织血运重建。事实上，鉴于许多体外和体内研究已证明干细胞在损伤部位的植入有限，这些分子的免疫调节和旁分泌作用可能主要解释了 MSC 的治疗效果。虽然对如此庞大的蛋白质阵列的研究仍然具有挑战性，但蛋白质组学领域的技术进步极大地提高了我们分析和表征干细胞分泌组的能力。因此，干细胞可以被认为是可调节的药理学仓库，可用于组合药物的制造和递送。作为再生医学治疗的无细胞选择，干细胞分泌组在各种临床应用中显示出巨大的潜力，包括心血管、神经退行性、肿瘤和泌尿生殖病理功能的恢复。
Mesenchymal stem cells (MSC) are a unique cell population defined by their ability to indefinitely self-renew, differentiate into multiple cell lineages, and form clonal cell populations. It was originally thought that this ability for broad plasticity defined the therapeutic potential of MSCs. However, an expanding body of recent literature has brought growing awareness to the remarkable array of bioactive molecules produced by stem cells. This protein milieu or “secretome” comprises a diverse host of cytokines, chemokines, angiogenic factors, and growth factors. The autocrine/paracrine role of these molecules is being increasingly recognized as key to the regulation of many physiological processes including directing endogenous and progenitor cells to sites of injury as well as mediating apoptosis, scarring, and tissue revascularization. In fact, the immunomodulatory and paracrine role of these molecules may predominantly account for the therapeutic effects of MSCs given that many in vitro and in vivo studies have demonstrated limited stem cell engraftment at the site of injury. While the study of such a vast protein array remains challenging, technological advances in the field of proteomics have greatly facilitated our ability to analyze and characterize the stem cell secretome. Thus, stem cells can be considered as tunable pharmacological storehouses useful for combinatorial drug manufacture and delivery. As a cell-free option for regenerative medicine therapies, stem cell secretome has shown great potential in a variety of clinical applications including the restoration of function in cardiovascular, neurodegenerative, oncologic, and genitourinary pathologies.
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影响因子：
3.7
作者：
Boomsma RA;Geenen DL
通讯作者：
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影响因子：
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作者：
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