Spectral performance of a whole-body research photon counting detector CT: quantitative accuracy in derived image sets.
Spectral performance of a whole-body research photon counting detector CT: quantitative accuracy in derived image sets.
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全身研究光子计数检测器CT的光谱性能：派生图像集中的定量精度。
DOI：
10.1088/1361-6560/aa8103
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发表时间：
2017-08-21
影响因子：
3.5
通讯作者：
McCollough C
中科院分区：
文献类型：
--
作者：
Leng S;Zhou W;Yu Z;Halaweish A;Krauss B;Schmidt B;Yu L;Kappler S;McCollough C
光子计数计算机断层扫描（PCCT）使用光子计数探测器对单个光子进行计数，并通过将光子能量与预设阈值进行比较将其分配到特定的能量箱。这使得能够使用单个源和探测器同时进行多能量CT。进行体模研究，通过评估衍生图像集的准确性来评估研究PCCT扫描仪的光谱性能。具体而言，我们评估了碘图图像中碘定量的准确性和虚拟单能图像（VMI）中CT数准确性。将含有5种已知浓度碘的小瓶置于代表不同体型患者衰减的体模中后，在PCCT扫描仪上进行扫描。为了进行比较，还在第二代和第三代双源双能量（DSDE）扫描仪上扫描了相同的小瓶和体模。材料分解后，生成碘图，从中测量每个小瓶和体模尺寸的碘浓度，并与已知浓度进行比较。此外，生成VMI，并将CT值准确度与参考标准品进行比较，参考标准品是根据从美国国家标准与技术研究所获得的每keV的已知碘浓度和衰减系数计算的。结果显示，使用PCCT扫描仪进行准确的碘定量（均方根误差为0.5 mgI/cc）和准确的VMI CT数量（百分比误差为8.9%）。PCCT扫描仪在碘定量和VMI CT数量准确性方面的总体性能与基于EID的双源双能量扫描仪相当。
Photon-counting computed tomography (PCCT) uses a photon counting detector to count individual photons and allocate them to specific energy bins by comparing photon energy to preset thresholds. This enables simultaneous multi-energy CT with a single source and detector. Phantom studies were performed to assess the spectral performance of a research PCCT scanner by assessing the accuracy of derived images sets. Specifically, we assessed the accuracy of iodine quantification in iodine map images and of CT number accuracy in virtual monoenergetic images (VMI). Vials containing iodine with 5 known concentrations were scanned on the PCCT scanner after being placed in phantoms representing the attenuation of different size patients. For comparison, the same vials and phantoms were also scanned on 2nd and 3rd generation dual-source, dual-energy (DSDE) scanners. After material decomposition, iodine maps were generated, from which iodine concentration was measured for each vial and phantom size and compared with the known concentration. Additionally, VMIs were generated and CT number accuracy was compared to the reference standard, which was calculated based on known iodine concentration and attenuation coefficients at each keV obtained from the U.S. National Institute of Standards and Technology. Results showed accurate iodine quantification (root mean square error of 0.5 mgI/cc) and accurate CT number of VMIs (percentage error of 8.9%) using the PCCT scanner. The overall performance of the PCCT scanner, in terms of iodine quantification and VMI CT number accuracy, was comparable to that of EID-based dual-source, dual-energy scanners.
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影响因子：
19.7
作者：
Leng S;Yu L;Fletcher JG;McCollough CH
通讯作者：
McCollough CH
影响因子：
5
作者：
Chandarana, Hersh;Megibow, Alec J.;Macari, Michael
通讯作者：
Macari, Michael
影响因子：
19.7
作者：
Boll, Daniel T.;Merkle, Elmar M.;Fleiter, Thorsten R.
通讯作者：
Fleiter, Thorsten R.
影响因子：
3.8
作者：
Goodsitt, Mitchell M.;Christodoulou, Emmanuel G.;Larson, Sandra C.
通讯作者：
Larson, Sandra C.
影响因子：
5
作者：
Primak, Andrew N.;Giraldo, Juan Carlos Ramirez;McCollough, Cynthia H.
通讯作者：
McCollough, Cynthia H.