Modeling brain development and diseases with human cerebral organoids
Modeling brain development and diseases with human cerebral organoids
复制标题
用人类大脑类器官模拟大脑发育和疾病
DOI：
10.1016/j.conb.2020.09.006
复制
发表时间：
2020-10
影响因子：
5.7
通讯作者：
Xiaoqun Wang
中科院分区：
文献类型：
--
作者：
Yingchao Shi;Qian Wu;Xiaoqun Wang
HighlightsA lot of outstanding pioneering studies greatly boost the brain organoid field.Brain organoids are versatile models to study human neurodevelopment, neurological disorders and brain cancers.Challenges and limitations will spur great advances in the brain organoid field.Understanding the mechanisms that underlie human brain development and neurological and neuropsychiatric disorders is one of the key topics of neurobiology. Because of the poor accessibility of human and non-human primate brain tissues, the current perception and understanding of human brain development have been mainly derived from studies of rodents. However, some human-specific features of neural development cannot be well characterized by these animal models. Thanks to the advances in stem cell technologies, brain organoids are being under rapid development, showing the promising applications in decoding the human brain development and uncovering the pathology of brain diseases. In this review, we mainly summarized the recent advances in the development of brain organoid technology and discussed the limitations, applications and future prospects of this promising field.
登录
查看更多内容
影响因子：
16.6
作者：
Ormel PR;Vieira de Sá R;van Bodegraven EJ;Karst H;Harschnitz O;Sneeboer MAM;Johansen LE;van Dijk RE;Scheefhals N;Berdenis van Berlekom A;Ribes Martínez E;Kling S;MacGillavry HD;van den Berg LH;Kahn RS;Hol EM;de Witte LD;Pasterkamp RJ
通讯作者：
Pasterkamp RJ
影响因子：
64.5
作者：
Mariani J;Coppola G;Zhang P;Abyzov A;Provini L;Tomasini L;Amenduni M;Szekely A;Palejev D;Wilson M;Gerstein M;Grigorenko EL;Chawarska K;Pelphrey KA;Howe JR;Vaccarino FM
通讯作者：
Vaccarino FM
影响因子：
48
作者：
Bian S;Repic M;Guo Z;Kavirayani A;Burkard T;Bagley JA;Krauditsch C;Knoblich JA
通讯作者：
Knoblich JA
影响因子：
46.9
作者：
Lancaster MA;Corsini NS;Wolfinger S;Gustafson EH;Phillips AW;Burkard TR;Otani T;Livesey FJ;Knoblich JA
通讯作者：
Knoblich JA
影响因子：
64.8
作者：
通讯作者：
--