Sepsis and disseminated intravascular coagulation are rare complications of typhoid fever: A case report.
Sepsis and disseminated intravascular coagulation are rare complications of typhoid fever: A case report.
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DOI：
10.1016/j.amsu.2021.103226
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Kumara IF
中科院分区：
文献类型：
--
作者：
Nurnaningsih;William V;Rusmawatiningtyas D;Makrufardi F;Kumara IF
伤寒是由伤寒沙门氏菌引起的一种传染病。常见的并发症是肠穿孔和伤寒脑病。虽然伤寒是印度尼西亚的地方病，但伤寒伴败血症和/或弥散性血管内凝血（DIC）的病例很少报告。一名来自地区医院的4岁男性转诊病例出现发热、意识下降和胃肠道和鼻子大量出血。调查显示，使用Tubex®TF进行IgM伤寒检测的结果为+8分。PELOD 2评分为10，PSOFA评分为5。DIC评分为7分。基于这些发现，患者被诊断为伤寒，DIC和败血症是伤寒的并发症。DIC主要是一种亚临床事件，在伤寒中发现的严重出血并发症是罕见的，尽管表明凝血和纤溶失衡的DIC评分在伤寒患者中显著升高。DIC可以是脓毒症综合征引起的多器官功能障碍的一部分。急性感染也可导致凝血系统激活。败血症和弥散性血管内凝血是伤寒罕见的并发症。伤寒是伤寒的常见症状，除消化道出血外，还可出现深度出血。伤寒和DIC之间的关系有待进一步研究。败血症和弥散性血管内凝血是伤寒罕见的并发症。伤寒可出现深出血的表现。急性感染也可导致凝血系统激活。
and importance: Typhoid fever is an infection caused by Salmonella typhi. The common complications are intestinal perforation and typhoid encephalopathy. Cases of typhoid fever with sepsis and/or disseminated intravascular coagulation (DIC) are rarely reported, even though typhoid fever is endemic in Indonesia. A 4-year-old male referral case from a district hospital was experiencing fever, decrease of consciousness and massive bleeding from his gastrointestinal tract and nose. Investigation revealed results from the IgM typhoid test using Tubex®TF, with the score of +8. PELOD 2 score was 10, and PSOFA was 5. DIC score was 7. Based on these findings, the patient was diagnosed with typhoid fever, with DIC and sepsis being the complication of the typhoid fever. DIC is mostly a subclinical event, and severe bleeding complications found in typhoid fever are uncommon, although DIC scores which indicate an imbalance of coagulation and fibrinolysis are markedly elevated in patients with typhoid. DIC can be a part of multi-organ dysfunction due to sepsis syndrome. Acute infection can also result in systemic activation of coagulation. Sepsis and DIC are rare complications of typhoid fever. Typhoid fever can be presented with profound bleeding manifestation other than gastrointestinal bleeding, since it is a common symptom of typhoid fever. Further research should be conducted to postulate association between typhoid fever and DIC. Sepsis and DIC are rare complications of typhoid fever. Typhoid fever can be presented with profound bleeding manifestation. Acute infection can also result in systemic activation of coagulation.
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DOI：
10.5005/jp-journals-10071-23842
发表时间：
2021-05
期刊：
Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
影响因子：
--
作者：
Ray B;Raha A
通讯作者：
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DOI：
10.1016/j.trstmh.2004.09.012
发表时间：
2005-06-01
影响因子：
2.2
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通讯作者：
van Dissel, JT
DOI：
10.1093/trstmh/trz075
发表时间：
2019-12-01
影响因子：
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作者：
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通讯作者：
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影响因子：
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影响因子：
15.3
作者：
Agha, Riaz A.;Franchi, Thomas;Mei, Zubing
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