Regulatory systems in bone marrow for hematopoietic stem/progenitor cells mobilization and homing.
Regulatory systems in bone marrow for hematopoietic stem/progenitor cells mobilization and homing.
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DOI：
10.1155/2013/312656
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发表时间：
2013
影响因子：
--
通讯作者：
Aránega A
中科院分区：
文献类型：
--
作者：
Alvarez P;Carrillo E;Vélez C;Hita-Contreras F;Martínez-Amat A;Rodríguez-Serrano F;Boulaiz H;Ortiz R;Melguizo C;Prados J;Aránega A
造血干细胞从骨髓（BM）释放、迁移和归巢的调控以及动员途径涉及粘附分子、细胞因子、蛋白水解酶、基质细胞和造血细胞之间复杂的相互作用。发现调节造血干细胞/祖细胞（HSPCs）运输的新机制不仅对造血移植有重要意义，而且对急性心肌梗死、脊髓损伤和中风等患者的再生医学细胞治疗也有重要意义。本文综述了BM造血干细胞/祖细胞归巢和动员的调控机制，探讨了以下问题：(a)基质细胞衍生因子-1 （SDF-1）、粒细胞集落刺激因子（G-CSF）和血管细胞粘附分子-1 （VCAM-1）等不同因子的作用以及其他配体；(b)外周血和骨髓干细胞计数及其影响因素；(c)这种现象在不同组织病变中的治疗应用，检查参与造血干细胞动员的药物，如不同形式的G-CSF、plerixafor和natalizumab；(d)在不同疾病患者的临床试验中，这种动员对bm来源的干细胞/祖细胞的影响。
Regulation of hematopoietic stem cell release, migration, and homing from the bone marrow (BM) and of the mobilization pathway involves a complex interaction among adhesion molecules, cytokines, proteolytic enzymes, stromal cells, and hematopoietic cells. The identification of new mechanisms that regulate the trafficking of hematopoietic stem/progenitor cells (HSPCs) cells has important implications, not only for hematopoietic transplantation but also for cell therapies in regenerative medicine for patients with acute myocardial infarction, spinal cord injury, and stroke, among others. This paper reviews the regulation mechanisms underlying the homing and mobilization of BM hematopoietic stem/progenitor cells, investigating the following issues: (a) the role of different factors, such as stromal cell derived factor-1 (SDF-1), granulocyte colony-stimulating factor (G-CSF), and vascular cell adhesion molecule-1 (VCAM-1), among other ligands; (b) the stem cell count in peripheral blood and BM and influential factors; (c) the therapeutic utilization of this phenomenon in lesions in different tissues, examining the agents involved in HSPCs mobilization, such as the different forms of G-CSF, plerixafor, and natalizumab; and (d) the effects of this mobilization on BM-derived stem/progenitor cells in clinical trials of patients with different diseases.
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影响因子：
4.8
作者：
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通讯作者：
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