Anticytokine autoantibodies: Autoimmunity trespassing on antimicrobial immunity.
Anticytokine autoantibodies: Autoimmunity trespassing on antimicrobial immunity.
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DOI：
10.1016/j.jaci.2021.11.016
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发表时间：
2022-01
影响因子：
14.2
通讯作者：
Holland, Steven M.
中科院分区：
文献类型：
--
作者：
Cheng, Aristine;Holland, Steven M.
关键词：
抗细胞因子自身抗体（ACAAs）可引起免疫缺陷或免疫反应失调。他们可能表现出基因定义的原发性免疫缺陷。我们回顾了目前的抗1型和2型干扰素、抗白细胞介素-12/23、抗白细胞介素-17、抗粒细胞-巨噬细胞-集落刺激因子自身抗体、HLA相关性、疾病相关性和基于机制的治疗方案。在症状开始时怀疑和识别患者应能改善疾病并改善预后。
Anti-cytokine autoantibodies (ACAAs) can cause immunodeficiency or dysregulate immune responses. They may phenocopy genetically defined primary immunodeficiencies. We review current anti-Type 1 and 2 interferon, anti-interleukin-12/23, anti-interleukin-17, anti-granulocyte-macrophage-colony-stimulating-factor autoantibodies, HLA associations, disease associations, and mechanistically based treatment options. Suspecting and identifying patients at the onset of symptoms should ameliorate disease and improve outcomes.
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5.8
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通讯作者：
Trouillet-Assant S
影响因子：
24.8
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通讯作者：
Casanova JL