The role of serotonin receptor subtypes in treating depression: a review of animal studies.
The role of serotonin receptor subtypes in treating depression: a review of animal studies.
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DOI：
10.1007/s00213-010-2097-z
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发表时间：
2011-02
影响因子：
3.4
通讯作者：
Lucki, Irwin
中科院分区：
文献类型：
--
作者：
Carr, Gregory V.;Lucki, Irwin
5-羟色胺再摄取抑制剂（SSRIs）是治疗抑郁症的有效药物。由于存在不同的5-HT受体家族和亚型，多种5-HT受体可能参与SSRIs的抗抑郁样行为效应。行为药理学研究调查的作用，5-HT受体亚型的生产或阻断SSRIs的影响进行了审查。很少有动物行为测试可用于支持SSRIs的原始开发。自从它们的发展以来，已经开发了许多行为测试和抑郁模型，这些测试和模型对SSRIs的作用以及其他类型的抗抑郁治疗敏感。这些测试的开发和使用的理由进行审查。5-HT 1A、5-HT 1B、5-HT 2C、5-HT 4和5-HT 6受体激动剂产生了类似于SSRI（抗抑郁药样）的行为效应。此外，据报道，5-HT 2A、5-HT 2C、5-HT 3、5-HT 6和5-HT 7受体的拮抗剂产生抗抑郁样应答。虽然这似乎是自相矛盾的，在特定的5-HT受体的激动剂和拮抗剂可以产生抗抑郁样作用，他们可能涉及不同的神经化学机制。当5-HT受体激动剂或拮抗剂联合使用时，SSRIs和其他抗抑郁药的行为效应也可能增强。5-HT受体参与SSRIs的抗抑郁样作用是复杂的，涉及不同5-HT受体亚型的刺激和阻断的协调。单个5-HT受体为开发新一代抗抑郁药提供了机会，这些抗抑郁药可能比SSRIs更有益和有效。
Serotonin reuptake inhibitors (SSRIs) are effective in treating depression. Given the existence of different families and subtypes of 5-HT receptors, multiple 5-HT receptors may be involved in the antidepressant-like behavioral effects of SSRIs. Behavioral pharmacology studies investigating the role of 5-HT receptor subtypes in producing or blocking the effects of SSRIs were reviewed. Few animal behavior tests were available to support the original development of SSRIs. Since their development, a number of behavioral tests and models of depression have been developed that are sensitive to the effects of SSRIs, as well as to other types of antidepressant treatments. The rationale for the development and use of these tests is reviewed. Behavioral effects similar to those of SSRIs (antidepressant-like) have been produced by agonists at 5-HT1A, 5-HT1B, 5-HT2C, 5-HT4, and 5-HT6 receptors. Also, antagonists at 5-HT2A, 5-HT2C, 5-HT3, 5- HT6, and 5-HT7 receptors have been reported to produce antidepressant-like responses. Although it seems paradoxical that both agonists and antagonists at particular 5-HT receptors can produce antidepressant-like effects, they probably involve diverse neurochemical mechanisms. The behavioral effects of SSRIs and other antidepressants may also be augmented when 5-HT receptor agonists or antagonists are given in combination. The involvement of 5-HT receptors in the antidepressant-like effects of SSRIs is complex and involves the orchestration of stimulation and blockade at different 5-HT receptor subtypes. Individual 5-HT receptors provide opportunities for the development of a newer generation of antidepressants that may be more beneficial and effective than SSRIs.
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影响因子：
7.6
作者：
Banasr, M;Hery, M;Daszuta, A
通讯作者：
Daszuta, A
影响因子：
8.2
作者：
Balu, Darrick T.;Lucki, Irwin
通讯作者：
Lucki, Irwin
影响因子：
3.4
作者：
Abbas, Atheir I.;Hedlund, Peter B.;Huang, Xi-Ping;Tran, Thuy B.;Meltzer, Herbert Y.;Roth, Bryan L.
通讯作者：
Roth, Bryan L.
影响因子：
2.5
作者：
Bonnavion, Patricia;Bernard, Jean-Francois;Fabre, Veronique
通讯作者：
Fabre, Veronique
影响因子：
17.1
作者：
Alexander B;Warner-Schmidt J;Eriksson T;Tamminga C;Arango-Lievano M;Ghose S;Vernov M;Stavarache M;Musatov S;Flajolet M;Svenningsson P;Greengard P;Kaplitt MG
通讯作者：
Kaplitt MG