Towards an understanding of the mechanoreciprocity process in adipocytes and its perturbation with aging.
Towards an understanding of the mechanoreciprocity process in adipocytes and its perturbation with aging.
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DOI：
10.1016/j.mad.2021.111522
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发表时间：
2021-07
影响因子：
5.3
通讯作者：
Rose, Giuseppina
中科院分区：
文献类型：
--
作者：
De Luca, Maria;Mandala, Maurizio;Rose, Giuseppina
关键词：
脂肪组织（AT）是一个复杂的器官，具有维持代谢健康所必需的多种功能。AT的一个特征是它能够响应生理挑战而扩展，例如怀孕和衰老，以及在整个生命中发生的正能量平衡的慢性状态期间。AT通过脂肪生成和/或现有脂肪细胞大小的增加而生长。健康AT生长所需的一个过程是细胞外基质（ECM）的重塑，这是恢复机械稳态和维持组织完整性和功能性的必要步骤。虽然机械生物学和脂肪形成之间的关系现在得到了很好的认可，但脂肪细胞机械信号通路在AT生长中的作用知之甚少。在这篇综述文章中，我们首先总结了ECM重塑AT扩张的证据，以及它的扰动如何与代谢不健康的表型相关。随后，我们强调的研究结果表明，分子参与的动态，双向过程（mechanoreciprocity），使脂肪细胞感知ECM的机械性能的变化是相互关联的调节脂质代谢的途径。最后，我们讨论了衰老可能影响脂肪细胞对ECM成分改变做出适当反应的能力的过程。
Adipose tissue (AT) is a complex organ, with multiple functions that are essential for maintaining metabolic health. A feature of AT is its capability to expand in response to physiological challenges, such as pregnancy and aging, and during chronic states of positive energy balance occurring throughout life. AT grows through adipogenesis and/or an increase in the size of existing adipocytes. One process that is required for healthy AT growth is the remodeling of the extracellular matrix (ECM), which is a necessary step to restore mechanical homeostasis and maintain tissue integrity and functionality. While the relationship between mechanobiology and adipogenesis is now well recognized, less is known about the role of adipocyte mechanosignaling pathways in AT growth. In this review article, we first summarize evidence linking ECM remodelling to AT expansion and how its perturbation is associated to a metabolically unhealthy phenotype. Subsequently, we highlight findings suggesting that molecules involved in the dynamic, bidirectional process (mechanoreciprocity) enabling adipocytes to sense changes in the mechanical properties of the ECM are interconnected to pathways regulating lipid metabolism. Finally, we discuss processes through which aging may influence the ability of adipocytes to appropriately respond to alterations in ECM composition.
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影响因子：
5.2
作者：
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通讯作者：
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DOI：
10.1146/annurev-pathol-121808-102144
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期刊：
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影响因子：
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DOI：
10.1073/pnas.0902639106
发表时间：
2009-12-29
影响因子：
11.1
作者：
Bellin, Robert M.;Kubicek, James D.;LeDuc, Philip R.
通讯作者：
LeDuc, Philip R.