Response of fibronectin to liver regeneration after hepatectomy
Response of fibronectin to liver regeneration after hepatectomy
复制标题
纤连蛋白对肝切除术后肝再生的反应
作者：
A. Kwon;Yoshiaki Inada;S. Uetsuji;M. Yamamura;K. Hioki;M. Yamamoto
在12名患者和有和无肝硬化的雄性Sprague-道利大鼠中研究了血浆纤连蛋白浓度与肝切除术后肝残留物再生过程之间的关系。人和大鼠肝切除术后血浆纤连蛋白水平立即降低。无肝硬化的患者和大鼠分别在1个月和1周内显示术前纤连蛋白水平，但低纤连蛋白水平在肝硬化患者中持续时间更长。肝硬化患者血浆纤维连接蛋白水平与肝再生程度密切相关（r = 0.4227; p < 0.05）与无肝硬化组比较（r = 0.8148; p < 0.001），并且还与硫代乙酰胺诱导的肝硬化大鼠再生期间肝脏重量变化的百分比相关。（r = 0.4905; p < 0.01）或无肝硬化大鼠（r = 0.6422; p < 0.001）。这些结果表明，血浆纤维连接蛋白是一个有用的标志物，用于检测再生肝。（肝脏学1990; 11：593：598。）
The relationship between plasma fibronectin concentration and the regenerative process in liver remnants after hepatectomy was studied in 12 patients and in male Sprague‐Dawley rats with and without cirrhosis. Plasma fibronectin levels were reduced immediately after hepatectomy in humans and rats. Patients and rats without cirrhosis displayed preoperative fibronectin levels within 1 mo and 1 wk, respectively, but low fibronectin levels persisted longer in those with cirrhosis. Plasma fibronectin levels correlated well with the degree of hepatic regeneration in the patients with cirrhosis (r = 0.4227; p < 0.05) and without cirrhosis (r = 0.8148; p < 0.001), and also with the percentage of change in liver weight during regeneration in the rat with thioacetamide‐induced cirrhosis (r = 0.4905; p < 0.01) or in the rat without cirrhosis (r = 0.6422; p < 0.001). These results suggest that plasma fibronectin is a useful marker for the detection of regenerating liver.(HEPATOLOGY 1990; 11:593:598.)
内源标记的血浆纤连蛋白从血管室中清除。
DOI：
10.1097/00005373-198402000-00001
发表时间：
1984
期刊：
The Journal of trauma
影响因子：
--
作者：
Deno,DC;Lewis,EP;Saba,TM
通讯作者：
Saba,TM
血浆纤连蛋白对主要身体烧伤的反应。
DOI：
10.1097/00005373-198011000-00011
发表时间：
1980
期刊：
The Journal of trauma
影响因子：
--
作者：
Grossman,JE;Demling,RH;Duy,ND;Mosher,DF
通讯作者：
Mosher,DF