Perinatal exposure to environmental tobacco smoke is associated with changes in DNA methylation that precede the adult onset of lung disease in a mouse model.
Perinatal exposure to environmental tobacco smoke is associated with changes in DNA methylation that precede the adult onset of lung disease in a mouse model.
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DOI：
10.1080/08958378.2017.1392655
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发表时间：
2017-08
影响因子：
2.1
通讯作者：
Cho YH
中科院分区：
文献类型：
--
作者：
Cole E;Brown TA;Pinkerton KE;Postma B;Malany K;Yang M;Kim YJ;Hamilton RF Jr;Holian A;Cho YH
产前和生命早期环境烟草烟雾(ETS)暴露可引起与炎症和呼吸道疾病相关的表观遗传学改变。这项研究的目的是解决围产期ETS暴露对潜在呼吸道疾病风险的长期表观遗传后果，这在很大程度上仍是未知的。将C57BL/6小鼠暴露于出生前和生命早期的ETS；在两个成年年龄测量子代肺病理、全局DNA和基因特异性甲基化。在10-12周龄和20周龄暴露的仔鼠中，发现干扰素-γ和Thy-1的全局甲基化和启动子甲基化发生了显著变化。这些持续的表观遗传学改变发生在20周龄时观察到的重大肺部病变之前。这项研究表明，围产期暴露于ETS会导致全球dna持续的表观遗传学改变，以及干扰素-γ和Thy-1启动子的甲基化，这些甲基化发生在成人纤维化肺病理之前。这些表观遗传学发现可能代表潜在的呼吸系统疾病风险的潜在生物标记物。
Prenatal and early-life environmental tobacco smoke (ETS) exposure can induce epigenetic alterations associated with inflammation and respiratory disease. The objective of this study was to address the long-term epigenetic consequences of perinatal ETS exposure on latent respiratory disease risk, which are still largely unknown. C57BL/6 mice were exposed to prenatal and early-life ETS; offspring lung pathology, global DNA, and gene-specific methylation were measured at two adult ages. Significant alterations in global DNA methylation and promoter methylation of IFN-γ and Thy-1 were found in ETS-exposed offspring at 10–12 and 20 weeks of age. These sustained epigenetic alterations preceded the onset of significant pulmonary pathologies observed at 20 weeks of age. This study suggests that perinatal ETS exposure induces persistent epigenetic alterations in global DNA, as well as IFN-γ and Thy-1 promoter methylation that precede the adult onset of fibrotic lung pathology. These epigenetic findings could represent potential biomarkers of latent respiratory disease risk.
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