Functional regulation of syntaxin-1: An underlying mechanism mediating exocytosis in neuroendocrine cells.
Functional regulation of syntaxin-1: An underlying mechanism mediating exocytosis in neuroendocrine cells.
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DOI：
10.3389/fendo.2023.1096365
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发表时间：
2023
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
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分泌囊泡与质膜的融合需要可溶性N-乙基马来酰亚胺敏感因子附着蛋白受体（SNARE）蛋白复合物的组装，所述蛋白复合物由小突触泡蛋白、突触融合蛋白-1和SNAP-25形成。在导致胞吐作用的途径中，突触融合蛋白-1的“开放”和“闭合”构象之间的转换充当囊泡与质膜融合的开关;突触融合蛋白-1簇在质膜上的快速组装和拆卸为神经内分泌细胞中的分泌囊泡提供对接和融合位点;而完全拉链式的trans-SNARE复合物，需要syntaxin-1与其他SNARE蛋白有序、快速和准确的结合，在触发融合中起着关键作用。在生理条件下影响胞吐作用的所有这些反应都受到多种因素的严格调节。在这里，我们回顾了目前关于突触融合蛋白-1参与神经内分泌细胞胞吐机制的证据，讨论了蛋白质、脂质、蛋白激酶、药物和毒素等多种因素在SNARE复合物介导的膜融合中的作用，并概述了突触融合蛋白-1突变相关疾病，以期开发治疗神经内分泌疾病的新型机制治疗靶点。
The fusion of the secretory vesicle with the plasma membrane requires the assembly of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein complexes formed by synaptobrevin, syntaxin-1, and SNAP-25. Within the pathway leading to exocytosis, the transitions between the “open” and “closed” conformations of syntaxin-1 function as a switch for the fusion of vesicles with the plasma membranes; rapid assembly and disassembly of syntaxin-1 clusters on the plasma membrane provide docking and fusion sites for secretory vesicles in neuroendocrine cells; and the fully zippered trans-SNARE complex, which requires the orderly, rapid and accurate binding of syntaxin-1 to other SNARE proteins, play key roles in triggering fusion. All of these reactions that affect exocytosis under physiological conditions are tightly regulated by multiple factors. Here, we review the current evidence for the involvement of syntaxin-1 in the mechanism of neuroendocrine cell exocytosis, discuss the roles of multiple factors such as proteins, lipids, protein kinases, drugs, and toxins in SNARE complex-mediated membrane fusion, and present an overview of syntaxin-1 mutation-associated diseases with a view to developing novel mechanistic therapeutic targets for the treatment of neuroendocrine disorders.
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影响因子：
64.8
作者：
Bao H;Das D;Courtney NA;Jiang Y;Briguglio JS;Lou X;Roston D;Cui Q;Chanda B;Chapman ER
通讯作者：
Chapman ER
影响因子：
16.6
作者：
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影响因子：
64.5
作者：
BENNETT, MK;GARCIAARRARAS, JE;SCHELLER, RH
通讯作者：
SCHELLER, RH
影响因子：
7.2
作者：
Bhattacharyya, Moitrayee;Karandur, Deepti;Kuriyan, John
通讯作者：
Kuriyan, John
影响因子：
16.2
作者：
Fujita, Y;Shirataki, H;Takai, Y
通讯作者：
Takai, Y