Function and mechanism of tumor suppressor gene LRRC4/NGL-2.
Function and mechanism of tumor suppressor gene LRRC4/NGL-2.
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抑癌基因LRRC4/NGL-2的功能及机制
DOI：
10.1186/1476-4598-13-266
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发表时间：
2014-12-19
期刊：
影响因子：
37.3
通讯作者：
Wu M
中科院分区：
文献类型：
--
作者：
Li P;Xu G;Li G;Wu M
LRRC4/NGL-2(Leucine Rich Repeat Containing 4/Netrin-G Ligand-2)是LRRC4/NGL(Netrin-G Ligand)家族的一员，属于LRR蛋白超家族，是一个在脑组织中相对特异表达的基因。LRRC4/NGL-2调控神经突起生长和板层特异性树突分割，提示LRRC4/NGL-2在神经系统发育中起重要作用。此外，LRRC4/NGL-2基因已被鉴定为肿瘤抑制基因。LRRC4/NGL-2的过表达通过复杂的信号调控网络抑制胶质瘤细胞的生长、血管生成和侵袭。LRRC4/NGL-2还具有与miRNA、转录因子和基因甲基化修饰形成多相环的能力，LRRC4/NGL-2功能的丧失可能是胶质瘤多个生物学过程中的重要事件。综上所述，LRRC4/NGL-2是神经系统正常发育和肿瘤发生过程中的关键基因。
LRRC4/NGL-2 (Leucine rich repeat containing 4/Netrin-G ligand-2), a relatively specific expressed gene in brain tissue, is a member of the LRRC4/ NGL (netrin-G ligand) family and belongs to the superfamily of LRR proteins. LRRC4/NGL-2 regulates neurite outgrowth and lamina-specific dendritic segmentation, suggesting that LRRC4/NGL-2 is important for the development of the nervous system. In addition, LRRC4/NGL-2 has been identified as a tumor suppressor gene. The overexpression of LRRC4/NGL-2 suppresses glioma cell growth, angiogenesis and invasion through complicated signaling regulation networks. LRRC4/NGL-2 also has the ability to form multiphase loops with miRNA, transcription factors and gene methylation modification; the loss of LRRC4/NGL-2 function may be an important event in multiple biological processes in gliomas. In summary, LRRC4/NGL-2 is a critical gene in the normal development and tumorigenesis of the nervous system.
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