Botulinum toxin injection and phenol nerve block for reduction of end-of-life pain.
Botulinum toxin injection and phenol nerve block for reduction of end-of-life pain.
复制标题
肉毒杆菌毒素注射和苯酚神经阻滞可减轻临终疼痛。
DOI：
10.1089/jpm.2013.0182
复制
发表时间：
2013
影响因子：
2.8
通讯作者：
Bruera,Eduardo
中科院分区：
文献类型：
--
作者：
Fu,Jack;Ngo,An;Shin,Ki;Bruera,Eduardo
背景：可注射的抗痉挛药物已被用于减轻疼痛。然而，还没有关于它用于临终疼痛的报道。病人：一位62岁女性，在大体全切除、放疗和化疗后有进行性左额颞部胶质母细胞瘤的病史，在物理医学和康复(PM&R)诊所治疗痉挛四肢瘫痪和疼痛。在提交给PM&R诊所时，她不再有资格接受进一步的癌症治疗。患者的神经功能一直在下降，伴有认知改变、虚弱和痉挛增加。根据她丈夫的报告，患者在就诊时的埃德蒙顿症状评估量表(ESAS)疼痛评分为8/10。在检查过程中，她表现出轻度到中度的痉挛。在认知方面，她无法听从指令，在考试期间会在几分钟的清醒和睡眠之间波动。她没有服用任何口腔肌肉松弛药，也没有因为她的低觉醒状态而开始服用任何药物。最初咨询9天后，她的双侧上肢和左侧大腿注射了700个单位的奥纳托毒素，左侧胫神经被苯酚神经阻滞。在28天后在姑息治疗诊所进行的随访中，ESAS疼痛评分为0。患者在注射后51天死亡。结论：该病例报告证实了可注射抗痉挛药物在减轻胶质母细胞瘤患者生命末期疼痛方面的应用。
Background:Injectable antispasticity agents have been utilized for the reduction of pain. However, there are no reports of its use for end-of-life pain.Patient Case:A 62-year-old female with a history of progressive left frontotemporal glioblastoma status post gross total resection, radiation, and chemotherapy presented to the physical medicine and rehabilitation (PM&R) clinic for management of spastic quadriplegia and pain. At the time of presentation to the PM&R clinic she was no longer eligible for further cancer treatment. The patient had been declining neurologically with cognitive changes, weakness, and increasing spasticity. The patient had an Edmonton Symptom Assessment Scale (ESAS) pain score of 8/10 at her visit, as reported by her husband. She exhibited mild to moderate spasticity during the exam. Cognitively, she was unable to follow commands and would fluctuate between being awake for a few minutes and sleeping during the exam. She was not on any oral muscle relaxants and none were started due to her state of hypoarousal. Nine days after the initial consultation she received 700 units of onabotulinum toxin into her bilateral upper limbs and left thigh and a phenol nerve block to her left tibial nerve. At a follow-up visit 28 days later in the palliative care clinic, the ESAS pain score was 0. The patient died 51 days post-injection.Conclusion:The case report demonstrates the use of injectable antispasticity agents in the reduction of end-of-life pain in a glioblastoma patient.
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影响因子：
4.2
作者：
Corradino B;Di Lorenzo S;Moschella F
通讯作者：
Moschella F
影响因子：
9.9
作者：
Simpson, D. M.;Gracies, J. -M.;So, Y.
通讯作者：
So, Y.
影响因子：
1.9
作者：
Ellies, M;Laskawi, R;Arglebe, C
通讯作者：
Arglebe, C
影响因子：
4.7
作者：
Wennman-Larsen, Agneta;Tishelman, Carol;Gustavsson, Petter
通讯作者：
Gustavsson, Petter
B 型肉毒毒素治疗颈肌张力障碍。
DOI：
10.1002/14651858.cd004315
发表时间：
2005
期刊：
The Cochrane database of systematic reviews
影响因子：
--
作者：
J. Costa;C. Espírito‐Santo;A. A. Borges;J. Ferreira;M. Coelho;Peter Moore;C. Sampaio
通讯作者：
C. Sampaio