Botulinum toxin A for oral cavity cancer patients: in microsurgical patients BTX injections in major salivary glands temporarily reduce salivary production and the risk of local complications related to saliva stagnation.
Botulinum toxin A for oral cavity cancer patients: in microsurgical patients BTX injections in major salivary glands temporarily reduce salivary production and the risk of local complications related to saliva stagnation.
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DOI：
10.3390/toxins4110956
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发表时间：
2012-10-24
期刊：
影响因子：
4.2
通讯作者：
Moschella F
中科院分区：
文献类型：
--
作者：
Corradino B;Di Lorenzo S;Moschella F
在患有口腔癌的患者中，手术治疗是复杂的，因为必须去除癌和淋巴结转移（通过根治性单侧或双侧颈淋巴结清扫术）并通过游离皮瓣重建受影响区域。术后唾液停滞是局部并发症的危险因素。与唾液停滞相关的轻微并发症（例如组织浸渍和伤口裂开）可能会成为影响手术或重建结果的重大并发症。事实上，口皮瘘管的形成可能会导致感染、游离皮瓣的失败，或患者因颈动脉爆裂综合征而死亡。在手术前四天在大唾液腺注射肉毒杆菌素，可以暂时减少愈合阶段的流涎，从而降低唾液相关并发症的发生率。43例口腔癌患者接受A型肉毒毒素治疗。在大涎腺肉毒毒素浸润前后进行唾液定量测量和涎腺造影。在所有病例中，唾液分泌都有相当大的但暂时的减少。术后局部并发症发生率较低。唾液分泌在两个月内恢复正常，对患者的副作用和不适最小。术后暂时抑制唾液分泌可以减少唾液相关的局部并发症和口皮瘘的发生率，并改善手术结果以及这些患者的剩余生活质量。
In patients suffering from oral cavity cancer surgical treatment is complex because it is necessary to remove carcinoma and lymph node metastasis (through a radical unilateral or bilateral neck dissection) and to reconstruct the affected area by means of free flaps. The saliva stagnation in the post-operative period is a risk factor with regard to local complications. Minor complications related to saliva stagnation (such as tissue maceration and wound dehiscence) could become major complications compromising the surgery or the reconstructive outcome. In fact the formation of oro-cutaneous fistula may cause infection, failure of the free flap, or the patient’s death with carotid blow-out syndrome. Botulinum injections in the major salivary glands, four days before surgery, temporarily reduces salivation during the healing stage and thus could reduce the incidence of saliva-related complications. Forty three patients with oral cancer were treated with botulinum toxin A. The saliva quantitative measurement and the sialoscintigraphy were performed before and after infiltrations of botulinum toxin in the major salivary glands. In all cases there was a considerable, but temporary, reduction of salivary secretion. A lower rate of local complications was observed in the post-operative period. The salivary production returned to normal within two months, with minimal side effects and discomfort for the patients. The temporary inhibition of salivary secretion in the post-operative period could enable a reduction in saliva-related local complications, in the incidence of oro-cutaneous fistulas, and improve the outcome of the surgery as well as the quality of residual life in these patients.
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影响因子：
1.4
作者：
Corradino, Bartolo;Di Lorenzo, Sara;Moschella, Francesco
通讯作者：
Moschella, Francesco
影响因子：
1.9
作者：
Dogu, O;Apaydin, D;Aral, M
通讯作者：
Aral, M
影响因子：
1.9
作者：
Ellies, M;Laskawi, R;Arglebe, C
通讯作者：
Arglebe, C
DOI：
10.1016/s0385-8146(99)00026-7
发表时间：
1999-10-01
期刊：
Auris, nasus, larynx
影响因子：
--
作者：
Malpani, B L;Jaiswar, R K;Samuel, A M
通讯作者：
Samuel, A M
影响因子：
4.8
作者：
Franceschi, S;Bidoli, E;Muñoz, N
通讯作者：
Muñoz, N