The acute antinociceptive effect of hyperbaric oxygen is not accompanied by an increase in markers of oxidative stress.
The acute antinociceptive effect of hyperbaric oxygen is not accompanied by an increase in markers of oxidative stress.
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DOI：
10.1016/j.lfs.2013.12.207
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发表时间：
2014-03-07
期刊：
影响因子：
6.1
通讯作者：
Quock, Raymond M.
中科院分区：
文献类型：
--
作者：
Liu, Shulin;Shirachi, Donald Y.;Quock, Raymond M.
暴露于高压氧（HBO2）引起小鼠的抗伤害性反应。然而，在高压下呼吸氧气（O2）可能会导致氧中毒。本研究的目的是确定HBO2抗伤害感受的决定因素和HBO2的毒性特征。使用乙酸诱导的腹部收缩试验，在室内空气或100%O2（1.0或3.5个绝对大气压（ATA））下评估雄性NIH Swiss小鼠的急性抗伤害感受性反应。对于氧毒性试验，小鼠暴露于3.5ATA氧，每天11分钟，60分钟，60分钟，持续2天（120分钟）或每天60分钟，持续4天（240分钟），然后通过分析脑，脊髓和肺中的两种氧化应激标志物MDA（丙二醛）和蛋白质羰基的水平来评估。只有100%O_2和3.5ATA的组合才能产生显著的抗伤害作用。100%O2的抗伤害效应是压力依赖性的高达3.5 ATA。在氧毒性试验中，暴露于HBO2不同时间间隔的小鼠的脑、脊髓和肺MDA和蛋白质羰基水平与暴露于室内空气的对照动物相当。用100%O2治疗引起压力依赖性抗伤害效应。由于受试组织中氧化应激标志物的水平没有显著增加，因此可以得出结论，在小鼠中不存在氧化应激的情况下，3.5 ATA的HBO 2产生抗伤害感受。
Exposure to hyperbaric oxygen (HBO2) causes an antinociceptive response in mice. However, breathing oxygen (O2) at an elevated pressure can potentially cause oxygen toxicity. The aim of this study was to identify the determinants of HBO2 antinociception and the toxicity profile of HBO2. Male NIH Swiss mice were assessed for acute antinociceptive responsiveness under room air or 100% O2 at 1.0 or 3.5 atmospheres absolute (ATA), using the acetic acid-induced abdominal constriction test. For the oxygen toxicity test, mice were exposed to 3.5 ATA oxygen for 11 min, 60 min, 60 min daily for 2 days (120 min) or 60 min daily for 4 days (240 min), then assessed by analyzing the levels of two oxidative stress markers, MDA (malondialdehyde) and protein carbonyl in brain, spinal cord and lung. Only the combination of 100% O2 and 3.5 ATA caused significant antinociception. The antinociceptive effect of 100% O2 was pressure-dependent up to 3.5 ATA. In the oxygen toxicity test, mice exposed to HBO2 for different time intervals had levels of brain, spinal cord and lung MDA and protein carbonyl that were comparable to that of control animals exposed to room air. Treatment with 100% O2 evokes a pressure-dependent antinociceptive effect. Since there was no significant increase in levels of the oxidative stress markers in the tested tissues, it is concluded HBO2 at 3.5 ATA produces antinociception in the absence of oxidative stress in mice.
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影响因子：
2.9
作者：
Quock LP;Zhang Y;Chung E;Ohgami Y;Shirachi DY;Quock RM
通讯作者：
Quock RM
影响因子：
6.6
作者：
Dall'Era, Marc A.;Hampson, Neil B.;Corman, John M.
通讯作者：
Corman, John M.
DOI：
10.1111/j.1440-1681.2011.05560.x
发表时间：
2011-10-01
影响因子：
2.9
作者：
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通讯作者：
Deng, Xiao-Ming
影响因子：
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作者：
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通讯作者：
Yildiz, Senol
影响因子：
1.7
作者：
Ohgami, Yusuke;Zylstra, Carlyn C.;Quock, Raymond M.
通讯作者：
Quock, Raymond M.