A Prospective Investigation of Body Size, Body Fat Composition and Colorectal Cancer Risk in the UK Biobank.
A Prospective Investigation of Body Size, Body Fat Composition and Colorectal Cancer Risk in the UK Biobank.
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DOI：
10.1038/s41598-017-17997-5
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发表时间：
2017-12-19
影响因子：
4.6
通讯作者：
Murphy N
中科院分区：
文献类型：
--
作者：
Ortega LS;Bradbury KE;Cross AJ;Morris JS;Gunter MJ;Murphy N
肥胖一直与结直肠癌风险增加有关，但这种关系在女性中较弱。在英国生物银行中，我们调查了472，526名男性和女性的身体尺寸（体重指数[BMI]，身高，腰围和腰臀比）和身体脂肪组成（全身脂肪百分比和躯干脂肪百分比）测量与结直肠癌风险之间的关联，平均随访5.6年。采用考克斯比例风险模型估计发生结直肠癌（2，636例发病病例）的多变量风险比（HR）和95%置信区间（95%CI）。在男性中，当比较最高和最低的五分之一时，（HR = 1.35，95%CI：1.13-1.61; P趋势< 0.0001），腰围（HR = 1.66，95%CI：1.39-1.99; Ptrend < 0.0001），腰臀比（HR = 1.58，95%CI：1.31-1.91; Ptrend < 0.0001），总体脂百分比（HR = 1.27，95%CI：1.06-1.53; Ptrend = 0.002）和躯干脂肪百分比（HR = 1.31，95%CI：1.09-1.58; Ptrend = 0.002）与更高的结直肠癌风险相关。对于女性，只有腰臀比（最高与最低五分之一的HR = 1.33，95%CI：1.08-1.65; Ptrend = 0.005）与结直肠癌风险呈正相关。较大的体型（整体和腹部肥胖）与男性结直肠癌的发生呈正相关。对于女性来说，腹部肥胖，而不是整体体型，与更大的结直肠癌风险相关。
Obesity has been consistently associated with a greater colorectal cancer risk, but this relationship is weaker among women. In the UK Biobank, we investigated the associations between body size (body mass index [BMI], height, waist circumference, and waist-to-hip ratio) and body fat composition (total body fat percentage and trunk fat percentage) measurements with colorectal cancer risk among 472,526 men and women followed for 5.6 years on average. Multivariable hazard ratios (HRs) and 95% confidence intervals (95%CI) for developing colorectal cancer (2,636 incident cases) were estimated using Cox proportional hazards models. Among men, when the highest and lowest fifths were compared, BMI (HR = 1.35, 95%CI: 1.13–1.61; Ptrend < 0.0001), waist circumference (HR = 1.66, 95%CI: 1.39–1.99; Ptrend < 0.0001), waist-to-hip ratio (HR = 1.58, 95%CI: 1.31–1.91; Ptrend < 0.0001), total body fat percentage (HR = 1.27, 95%CI: 1.06–1.53; Ptrend = 0.002), and trunk fat percentage (HR = 1.31, 95%CI: 1.09–1.58; Ptrend = 0.002) were associated with greater colorectal cancer risk. For women, only waist-to-hip ratio (HR for highest versus lowest fifth = 1.33, 95%CI: 1.08–1.65; Ptrend = 0.005) was positively associated with colorectal cancer risk. Greater body size (overall and abdominal adiposity) was positively associated with colorectal cancer development in men. For women, abdominal adiposity, rather than overall body size, was associated with a greater colorectal cancer risk.
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影响因子：
7.1
作者：
Larsson, Susanna C.;Wolk, Alicja
通讯作者：
Wolk, Alicja
影响因子：
158.5
作者：
Chlebowski, RT;Wactawski-Wende, J;Carleton, R
通讯作者：
Carleton, R
影响因子：
10.3
作者：
Murphy, Neil;Strickler, Howard D.;Gunter, Marc J.
通讯作者：
Gunter, Marc J.
影响因子：
24.5
作者：
Terry, PD;Miller, AB;Rohan, TE
通讯作者：
Rohan, TE
DOI：
10.1093/jnci/djj246
发表时间：
2006-07-05
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Pischon, Tobias;Lahmann, Petra H.;Riboli, Elio
通讯作者：
Riboli, Elio