Computational methods and challenges for large-scale circuit mapping.
Computational methods and challenges for large-scale circuit mapping.
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DOI：
10.1016/j.conb.2011.11.010
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发表时间：
2012-02
影响因子：
5.7
通讯作者：
Mitra PP
中科院分区：
文献类型：
--
作者：
Helmstaedter M;Mitra PP
The connectivity architecture of neuronal circuits is essential to understand how brains work, yet our knowledge about the neuronal wiring diagrams remains limited and partial. Technical breakthroughs in labeling and imaging methods starting more than a century ago have advanced knowledge in the field. However, the volume of data associated with imaging a whole brain or a significant fraction thereof, with electron or light microscopy, has only recently become amenable to digital storage and analysis. A mouse brain imaged at light microscopic resolution is about a terabyte of data, and 1 mm3 of the brain at EM resolution is about half a petabyte. This has given rise to a new field of research, computational analysis of large scale neuroanatomical data sets, with goals that include reconstructions of the morphology of individual neurons as well as entire circuits. The problems encountered include large data management, segmentation and 3D reconstruction, computational geometry and workflow management allowing for hybrid approaches combining manual and algorithmic processing. Here we review this growing field of neuronal data analysis with emphasis on reconstructing neurons from EM data cubes.
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影响因子：
3
作者：
Gillette, Todd A.;Brown, Kerry M.;Ascoli, Giorgio A.
通讯作者：
Ascoli, Giorgio A.
影响因子：
64.8
作者：
Bock, Davi D.;Lee, Wei-Chung Allen;Kerlin, Aaron M.;Andermann, Mark L.;Hood, Greg;Wetzel, Arthur W.;Yurgenson, Sergey;Soucy, Edward R.;Kim, Hyon Suk;Reid, R. Clay
通讯作者：
Reid, R. Clay
影响因子：
9.2
作者：
Chiang, Ann-Shyn;Lin, Chih-Yung;Hwang, Jenn-Kang
通讯作者：
Hwang, Jenn-Kang
影响因子：
4.3
作者：
Bohland JW;Wu C;Barbas H;Bokil H;Bota M;Breiter HC;Cline HT;Doyle JC;Freed PJ;Greenspan RJ;Haber SN;Hawrylycz M;Herrera DG;Hilgetag CC;Huang ZJ;Jones A;Jones EG;Karten HJ;Kleinfeld D;Kötter R;Lester HA;Lin JM;Mensh BD;Mikula S;Panksepp J;Price JL;Safdieh J;Saper CB;Schiff ND;Schmahmann JD;Stillman BW;Svoboda K;Swanson LW;Toga AW;Van Essen DC;Watson JD;Mitra PP
通讯作者：
Mitra PP
DOI：
10.1111/j.1365-2818.2005.01466.x
发表时间：
2005-04-01
期刊：
JOURNAL OF MICROSCOPY-OXFORD
影响因子：
--
作者：
Fiala, JC
通讯作者：
Fiala, JC