Post-Translational Modifications in Oocyte Maturation and Embryo Development.
Post-Translational Modifications in Oocyte Maturation and Embryo Development.
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卵母细胞成熟和胚胎发育的翻译后修饰
DOI：
10.3389/fcell.2021.645318
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发表时间：
2021
影响因子：
5.5
通讯作者：
Yang M
中科院分区：
文献类型：
--
作者：
Wu Y;Li M;Yang M
哺乳动物卵母细胞成熟和胚胎发育是一个独特的生物学过程，受多种修饰的调控。由于卵母细胞减数分裂过程中不存在从头mRNA转录，因此蛋白质水平的调节，特别是翻译后修饰（PTM）至关重要。众所周知，PTM在卵母细胞成熟和胚胎发育过程中的DNA损伤反应、染色体浓缩和细胞骨架组织等多种细胞事件中起关键作用。然而，大多数以前的评论PTM卵母细胞和胚胎只集中在非洲爪蟾或秀丽隐杆线虫卵的研究。本文主要从磷酸化、泛素化、SUMO化和聚腺苷二磷酸核糖基化（Poly（ADP-ribosyl）ation，PAR ylation）等方面综述了哺乳动物卵母细胞成熟和胚胎发育过程中PTM的最新研究进展。在哺乳动物卵母细胞成熟过程中，磷酸化通过调节组蛋白H3、丝裂原活化蛋白激酶和其他一些途径在染色体浓缩和纺锤体排列中发挥作用。泛素化是促进蛋白质降解的三步酶级联反应，许多E3泛素连接酶参与修饰底物，从而调节卵母细胞成熟、卵母细胞-精子结合和早期胚胎发育。SUMO修饰通过在赖氨酸残基上可逆地添加和去除SUMO（small ubiquitin-related modifier）来影响卵母细胞的细胞周期和DNA损伤反应。作为一种新兴的PTM，PARlation不仅参与DNA损伤修复，还介导卵母细胞减数分裂的不对称分裂。这些PTM和外部环境中的每一个都是通用的，并有助于卵母细胞成熟和胚胎发育过程中的不同阶段。
Mammalian oocyte maturation and embryo development are unique biological processes regulated by various modifications. Since de novo mRNA transcription is absent during oocyte meiosis, protein-level regulation, especially post-translational modification (PTM), is crucial. It is known that PTM plays key roles in diverse cellular events such as DNA damage response, chromosome condensation, and cytoskeletal organization during oocyte maturation and embryo development. However, most previous reviews on PTM in oocytes and embryos have only focused on studies of Xenopus laevis or Caenorhabditis elegans eggs. In this review, we will discuss the latest discoveries regarding PTM in mammalian oocytes maturation and embryo development, focusing on phosphorylation, ubiquitination, SUMOylation and Poly(ADP-ribosyl)ation (PARylation). Phosphorylation functions in chromosome condensation and spindle alignment by regulating histone H3, mitogen-activated protein kinases, and some other pathways during mammalian oocyte maturation. Ubiquitination is a three-step enzymatic cascade that facilitates the degradation of proteins, and numerous E3 ubiquitin ligases are involved in modifying substrates and thus regulating oocyte maturation, oocyte-sperm binding, and early embryo development. Through the reversible addition and removal of SUMO (small ubiquitin-related modifier) on lysine residues, SUMOylation affects the cell cycle and DNA damage response in oocytes. As an emerging PTM, PARlation has been shown to not only participate in DNA damage repair, but also mediate asymmetric division of oocyte meiosis. Each of these PTMs and external environments is versatile and contributes to distinct phases during oocyte maturation and embryo development.
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DOI：
10.1126/science.1171396
发表时间：
2009-05-15
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
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通讯作者：
Richards JS
影响因子：
5.3
作者：
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Grootegoed, JA
影响因子：
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作者：
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通讯作者：
Blagoev, Blagoy
DOI：
10.1262/jrd.2018-006
发表时间：
2018-06-22
期刊：
The Journal of reproduction and development
影响因子：
--
作者：
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通讯作者：
Naito K
影响因子：
5.3
作者：
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Gill, Grace