Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning.
Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning.
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在运动技能学习的最早阶段需要快速产生新的少突胶质细胞
DOI：
10.1038/nn.4351
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发表时间：
2016-09
影响因子：
25
通讯作者：
Richardson, William D.
中科院分区：
文献类型：
--
作者：
Xiao, Lin;Ohayon, David;McKenzie, Ian A.;Sinclair-Wilson, Alexander;Wright, Jordan L.;Fudge, Alexander D.;Emery, Ben;Li, Huiliang;Richardson, William D.
我们确定了一种新形成的少突胶质细胞的新标记物-胞外酶Enpp 6-并使用它来跟踪成年小鼠的少突胶质细胞分化，因为它们学习了运动技能（在具有不均匀间隔梯级的轮子上跑步）。在皮质下白色物质中，在暴露于复杂轮的2.5小时内，在运动皮质中，表达Enpp 6的未成熟少突胶质细胞的产生加速。少突胶质细胞前体中髓鞘调节因子（Myrf）的条件性缺失阻断了新Enpp 6+少突胶质细胞的形成，并在相同的~2-3小时时间范围内损害了学习。这种对少突胶质细胞的非常早期的需求表明了在学习中的直接和积极的作用，与突触强化密切相关。正常小鼠的跑步表现在接下来的一周内继续改善，伴随着少突胶质细胞前体增殖和分化的第二波。我们的结论是，新的少突胶质细胞有助于运动技能学习的早期和晚期阶段。
We identified a novel marker of newly-forming oligodendrocytes – the ecto-enzyme Enpp6 – and used this to track oligodendrocyte differentiation in adult mice as they learned a motor skill (running on a wheel with unevenly spaced rungs). Production of Enpp6 - expressing immature oligodendrocytes was accelerated within just 2.5 hours exposure to the complex wheel in subcortical white matter and within 4 hours in motor cortex. Conditional deletion of Myelin regulatory factor (Myrf) in oligodendrocyte precursors blocked formation of new Enpp6+ oligodendrocytes and impaired learning within the same ~2-3 hour time frame. This very early requirement for oligodendrocytes suggests a direct and active role in learning, closely linked to synaptic strengthening. Running performance of normal mice continued to improve over the following week accompanied by secondary waves of oligodendrocyte precursor proliferation and differentiation. We conclude that new oligodendrocytes contribute to both early and late stages of motor skill learning.
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影响因子：
4.5
作者：
Hornig J;Fröb F;Vogl MR;Hermans-Borgmeyer I;Tamm ER;Wegner M
通讯作者：
Wegner M
影响因子：
3.7
作者：
Matsumoto Y;Tsunekawa Y;Nomura T;Suto F;Matsumata M;Tsuchiya S;Osumi N
通讯作者：
Osumi N
影响因子：
16.2
作者：
Kang, Shin H.;Fukaya, Masahiro;Yang, Jason K.;Rothstein, Jeffrey D.;Bergles, Dwight E.
通讯作者：
Bergles, Dwight E.
影响因子：
158.5
作者：
Chang, A;Tourtellotte, WW;Trapp, BD
通讯作者：
Trapp, BD
影响因子：
64.8
作者：
Fuenfschilling, Ursula;Supplie, Lotti M.;Mahad, Don;Boretius, Susann;Saab, Aiman S.;Edgar, Julia;Brinkmann, Bastian G.;Kassmann, Celia M.;Tzvetanova, Iva D.;Moebius, Wiebke;Diaz, Francisca;Meijer, Dies;Suter, Ueli;Hamprecht, Bernd;Sereda, Michael W.;Moraes, Carlos T.;Frahm, Jens;Goebbels, Sandra;Nave, Klaus-Armin
通讯作者：
Nave, Klaus-Armin