Impact of aging on dendritic cell functions in humans.
Impact of aging on dendritic cell functions in humans.
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DOI：
10.1016/j.arr.2010.06.004
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发表时间：
2011-07
影响因子：
13.1
通讯作者：
Gupta, Sudhir
中科院分区：
文献类型：
--
作者：
Agrawal, Anshu;Gupta, Sudhir
衰老是免疫力下降和慢性炎症的悖论。树突状细胞是免疫反应的中央协调者，在免疫的产生和耐受的维持中起着关键作用。区议会的功能随着年龄的增长而受损。这对老年人DC亚群的数量和表型没有重大影响；然而，他们吞噬抗原和迁移的能力随着年龄的增长而减弱。各种DC亚群异常分泌细胞因子，CDC分泌的促炎细胞因子基础水平升高，但对外来抗原刺激的反应性降低。相反，对自身抗原的反应增加，表明外周自身耐受性受到侵蚀。PDC亚群还分泌减少的干扰素-α，以应对病毒。树突状细胞启动T细胞反应的能力也受到影响。因此，衰老对DC功能有深远的影响。本综述从免疫和耐受两个方面综述了增龄对人类DC功能的影响。
Aging is a paradox of reduced immunity and chronic inflammation. Dendritic cells are central orchestrators of the immune response with a key role in the generation of immunity and maintenance of tolerance. The functions of DCs are compromised with age. There is no major effect on the numbers and phenotype of DC subsets in aged subjects; nevertheless, their capacity to phagocytose antigens and migrate is impaired with age. There is aberrant cytokine secretion by various DC subsets with CDCs secreting increased basal level of pro-inflammatory cytokines but the response on stimulation to foreign antigens is decreased. In contrast, the response to self antigens is increased suggesting erosion of peripheral self tolerance. PDC subset also secretes reduced IFN-alpha in response to viruses. The capacity of DCs to prime T cell responses is also affected. Aging thus has a profound affect on DC functions. Present review summarizes the effect of advancing age on DC functions in humans in the context of both immunity and tolerance.
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影响因子：
30.5
作者：
Acosta-Rodriguez, Eva V.;Napolitani, Giorgio;Sallusto, Federica
通讯作者：
Sallusto, Federica
影响因子：
15.9
作者：
Dillon, S;Agrawal, S;Pulendran, B
通讯作者：
Pulendran, B
影响因子：
13.6
作者：
Boren, E;Gershwin, ME
通讯作者：
Gershwin, ME
影响因子：
3
作者：
Bodineau, Agnes;Coulomb, Bernard;Seguier, Sylvie
通讯作者：
Seguier, Sylvie
影响因子：
10.3
作者：
Bhushan, M;Cumberbatch, M;Griffiths, CEM
通讯作者：
Griffiths, CEM