MiR-92b and miR-9/9* are specifically expressed in brain primary tumors and can be used to differentiate primary from metastatic brain tumors.
MiR-92b and miR-9/9* are specifically expressed in brain primary tumors and can be used to differentiate primary from metastatic brain tumors.
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DOI：
10.1111/j.1750-3639.2008.00184.x
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发表时间：
2009-07
期刊：
影响因子：
--
通讯作者：
Rosenfeld N
中科院分区：
文献类型：
--
作者：
Nass D;Rosenwald S;Meiri E;Gilad S;Tabibian-Keissar H;Schlosberg A;Kuker H;Sion-Vardy N;Tobar A;Kharenko O;Sitbon E;Lithwick Yanai G;Elyakim E;Cholakh H;Gibori H;Spector Y;Bentwich Z;Barshack I;Rosenfeld N
脑病理学家面临的一个反复出现的挑战是诊断脑恶性肿瘤是原发性肿瘤还是其他组织的转移。脑恶性肿瘤的准确诊断对于选择适当的治疗方案至关重要。MicroRNA是一类调节基因表达的小的非编码RNA种类;许多表现出组织特异性表达并且在癌症中被错误调节。使用microRNA表达谱，我们发现hsa-miR-92 b和hsa-miR-9/hsa-miR-9* 过表达，特别是在脑原发性肿瘤中，与其他组织的原发性肿瘤及其脑转移瘤相比。通过仅考虑这两种microRNA的表达，有可能以非常高的准确性区分原发性和转移性脑肿瘤。因此，这些microRNA代表了脑原发性肿瘤的优秀生物标志物。先前的研究发现，hsa-miR-92 b和hsa-miR-9/hsa-miR-9* 在发育中的神经元和大脑中的表达比在成年大脑中更强。因此，它们在脑原发性肿瘤中的特异性过表达支持这些microRNA的功能作用或神经元干细胞与脑肿瘤发生之间的联系。
A recurring challenge for brain pathologists is to diagnose whether a brain malignancy is a primary tumor or a metastasis from some other tissue. The accurate diagnosis of brain malignancies is essential for selection of proper treatment. MicroRNAs are a class of small non‐coding RNA species that regulate gene expression; many exhibit tissue‐specific expression and are misregulated in cancer. Using microRNA expression profiling, we found that hsa‐miR‐92b and hsa‐miR‐9/hsa‐miR‐9* are over‐expressed, specifically in brain primary tumors, as compared to primary tumors from other tissues and their metastases to the brain. By considering the expression of only these two microRNAs, it is possible to distinguish between primary and metastatic brain tumors with very high accuracy. These microRNAs thus represent excellent biomarkers for brain primary tumors. Previous reports have found that hsa‐miR‐92b and hsa‐miR‐9/hsa‐miR‐9* are expressed more strongly in developing neurons and brain than in adult brain. Thus, their specific over‐expression in brain primary tumors supports a functional role for these microRNAs or a link between neuronal stem cells and brain tumorigenesis.
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影响因子：
64.8
作者：
Lu, J;Getz, G;Golub, TR
通讯作者：
Golub, TR
影响因子：
2.7
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Shi, R;Chiang, VL
通讯作者：
Chiang, VL
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30.8
作者：
Bentwich, I;Avniel, A;Bentwich, Z
通讯作者：
Bentwich, Z
影响因子：
6.4
作者：
NG, HK;LO, STH
通讯作者：
LO, STH
影响因子：
10.5
作者：
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通讯作者：
Hammond, Scott M.