Coagulation abnormalities in ischaemic optic neuropathy
Coagulation abnormalities in ischaemic optic neuropathy
复制标题
缺血性视神经病变的凝血异常
作者：
J. Acheson;M. Sanders
非动脉炎性缺血性视神经病变（ION）的病因是多因素的，局部解剖和全身血液动力学异常都起作用。需要仔细寻找可治疗的血管疾病风险因素，以允许合理的治疗，优化视力预后，并允许对发病机制的新见解。我们描述了7例患有相关嗜血栓（血栓形成前）状态的病例; 4例患有生理性抗凝剂蛋白C和S以及抗凝血酶III缺陷，2例患有抗磷脂抗体（狼疮抗凝剂）综合征。另一名患者的生理纤维蛋白溶解剂组织纤溶酶原激活物（t-PA）水平降低。在5例患者中，还存在小血管闭塞性疾病的其他风险因素，4例患者在同一只眼睛中反复发作ION。这些患者的视力预后可通过华法林抗凝治疗得到改善。
The aetiology of non-arteritic ischaemic optic neuropathy (ION) is multifactorial with local anatomical and systemic haemodynamic abnormalities both playing a role. A careful search for treatable vascular disease risk factors is required to allow rational therapy, to optimise the visual prognosis and to allow new insights into pathogenesis. We describe 7 cases in which there was an associated thrombophilic (prothrombotic) state; 4 had deficiencies of the physiological anticoagulants proteins C and S and antithrombin III and 2 had anti-phospholipid antibody (lupus anticoagulant) syndromes. A further patient had reduced levels of the physiological fibrinolytic agent tissue plasminogen activator (t-PA). In 5 patients other risk factors for small vessel occlusive disease were also present, and 4 had recurrent episodes of ION in the same eye. The visual prognosis in these patients may be improved by anticoagulation with warfarin.
与抗磷脂抗体相关的血管闭塞性视网膜病（狼疮抗凝性视网膜病）。
影响因子：
13.7
作者：
Kleiner,RC;Najarian,LV;Schatten,S;Jabs,DA;Patz,A;Kaplan,HJ
通讯作者：
Kaplan,HJ