Optical glucose sensors based on hexagonally-packed 2.5-dimensional photonic concavities imprinted in phenylboronic acid functionalized hydrogel films.
Optical glucose sensors based on hexagonally-packed 2.5-dimensional photonic concavities imprinted in phenylboronic acid functionalized hydrogel films.
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DOI：
10.1039/c7ra11184c
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发表时间：
2017-11-25
期刊：
影响因子：
3.9
通讯作者：
Butt H
中科院分区：
文献类型：
--
作者：
Bajgrowicz-Cieslak M;Alqurashi Y;Elshereif MI;Yetisen AK;Hassan MU;Butt H
葡萄糖反应水凝胶在暴露于不同葡萄糖浓度时改变其体积，用于测量生理条件下的葡萄糖水平。血糖持续监测的目的是准确控制血糖浓度，预防糖尿病患者低血糖/高血糖。基于水凝胶的系统已经成为一种可重复使用的传感平台，用于在临床和护理点环境中量化高风险患者的生物标志物。将基于水凝胶的系统与光学换能器集成的能力将通过对生物标志物的分光光度分析提供定量和比色测量。在这里，我们创造了一种印迹方法，在苯硼酸功能化的水凝胶膜上快速产生2.5D光子凹。我们的方法利用了晶格间距为3.3 μm的六边形填充2.5D光子微尺度凹的衍射特性。在透射模式下，单色光源照射2.5D六边形填充结构，可以基于一阶晶格间隙跟踪可逆和定量测量葡萄糖浓度的变化。可逆共价苯硼酸与葡萄糖分子的顺式二醇偶联，在葡萄糖浓度为1 mM和200 mM的情况下，水凝胶基质分别膨胀了约2%和34%。由于葡萄糖浓度的增加（1-200 mM）， Donnan渗透压诱导水凝胶基质的体积膨胀，导致晶格间隙的纳米级调制，并改变了衍射角（~ 45°至36°）以及一级衍射点之间的间距（~ 8至3 mM）。该传感器在15分钟的可逆响应时间内显示出最大晶格间距衍射位移。所开发的2.5D光子传感器可应用于医疗现场诊断、植入式芯片和可穿戴连续血糖监测设备。
A glucose-responsive hydrogel that changes its volume when exposed to different glucose concentrations was used to measure the glucose levels under physiological conditions. Continuous glucose monitoring aims to achieve accurate control of blood glucose concentration to prevent hypo/hyperglycaemia in diabetic patients. Hydrogel-based systems have emerged as a reusable sensing platform to quantify biomarkers in high-risk patients at clinical and point-of-care settings. The capability to integrate hydrogel-based systems with optical transducers will provide quantitative and colorimetric measurements via spectrophotometric analyses of biomarkers. Here, we created an imprinting method to rapidly produce 2.5D photonic concavities in phenylboronic acid functionalized hydrogel films. Our method exploited diffraction properties of hexagonally-packed 2.5D photonic microscale concavities having a lattice spacing of 3.3 μm. Illumination of the 2.5D hexagonally-packed structure with a monochromatic light source in transmission mode allowed reversible and quantitative measurements of variation in the glucose concentration based on first order lattice interspace tracking. Reversible covalent phenylboronic acid coupling with cis-diols of glucose molecules expanded the hydrogel matrix by ∼2% and 34% in the presence of glucose concentrations of 1 mM and 200 mM, respectively. A Donnan osmotic pressure induced volumetric expansion of the hydrogel matrix due to increasing glucose concentrations (1–200 mM), resulted in a nanoscale modulation of the lattice interspace, and shifted the diffraction angle (∼45° to 36°) as well as the interspacing between the 1st order diffraction spots (∼8 to 3 mm). The sensor exhibited a maximum lattice spacing diffraction shift within a response time of 15 min in a reversible manner. The developed 2.5D photonic sensors may have application in medical point-of-care diagnostics, implantable chips, and wearable continuous glucose monitoring devices.
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