Ion mobility spectrometry: A personal view of its development at UCSB.

Ion mobility spectrometry: A personal view of its development at UCSB.
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DOI:
10.1016/j.ijms.2014.06.016
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发表时间:
2014-09-15
影响因子:
1.8
通讯作者:
Bowers MT
Bowers MT
中科院分区:
化学4区
文献类型:
--
作者:
Bowers MT

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离子迁移率不是一个新发现的现象。它的历史可以追溯到20世纪初的朗之万市。我们的团队最初是在1990年左右偶然参与的,本文简要介绍了过去25年来在UCSB发生的事情,以应对这一令人愉快的事故。我们从小的过渡金属原子离子开始,过渡到碳簇,合成聚合物,大多数类型的生物分子,最后是肽和蛋白质的寡聚组装。在此过程中,我们设计和制造了几代仪器,这一过程仍在进行中。也许最重要的是,我们从一开始就将理论与实验结合在一起;这是一个必要的婚礼,允许在原本有趣但不完全信息的横截面测量上呈现出原子化的面孔。
Ion mobility is not a newly discovered phenomenon. It has roots going back to Langevin at the beginning of the 20th century. Our group initially got involved by accident around 1990 and this paper is a brief account of what has transpired here at UCSB the past 25 years in response to this happy accident. We started small, literally, with transition metal atomic ions and transitioned to carbon clusters, synthetic polymers, most types of biological molecules and eventually peptide and protein oligomeric assembly. Along the way we designed and built several generations of instruments, a process that is still ongoing. And perhaps most importantly we have incorporated theory with experiment from the beginning; a necessary wedding that allows an atomistic face to be put on the otherwise interesting but not fully informative cross section measurements.
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