NR4A1 destabilizes TNF mRNA in microglia and modulates stroke outcomes.

NR4A1 destabilizes TNF mRNA in microglia and modulates stroke outcomes.
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DOI:
10.1371/journal.pbio.3002226
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发表时间:
2023-07
期刊:
影响因子:
9.8
通讯作者:
Yao, Yao
Yao, Yao
中科院分区:
生物学1区
文献类型:
--
作者:
Yao, Yao

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小胶质细胞在卒中中发挥双重作用,这取决于它们的促炎和抗炎极化。PLOS Biology上的一项研究确定了一种新的机制,通过这种机制,转录因子NR4A1负调控小胶质细胞中的TNF表达。小胶质细胞在卒中中发挥双重作用,这取决于它们的促炎和抗炎极化。这篇文章探讨了PLOS Biology的一项研究,该研究确定了一种新的机制,通过这种机制,转录因子NR4A1负调控小胶质细胞中的TNF表达。
Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in PLOS Biology identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia. Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. This Primer explores a PLOS Biology study that identifies a new mechanism through which the transcription factor NR4A1 negatively regulates TNF expression in microglia.
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