NEMA NU 1-2018 performance characterization and Monte Carlo model validation of the Cubresa Spark SiPM-based preclinical SPECT scanner.
NEMA NU 1-2018 performance characterization and Monte Carlo model validation of the Cubresa Spark SiPM-based preclinical SPECT scanner.
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DOI：
10.1186/s40658-023-00555-6
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发表时间：
2023-06-01
期刊：
影响因子：
4
通讯作者：
中科院分区：
文献类型：
--
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Cubresa Spark 是一种新型台式硅光电倍增管 (SiPM) 临床前 SPECT 系统。与带有需要高放大准直器的光电倍增管的临床前相机相比，SPECT 中的 SiPM 显着提高了分辨率并减小了探测器尺寸。 NEMA NU 1 伽玛相机性能测量标准提供了可轻松应用或扩展的方法，只需稍作修改即可表征临床前相机。本研究的主要目标是根据 NEMA NU 1-2018 标准对 Spark 进行表征，以深入了解其核医学成像功能。第二个目标是验证 Spark 的 GATE 蒙特卡洛模拟模型，以用于临床前 SPECT 研究。 NEMA NU 1-2018 指南用于描述 Spark 的单针孔和多针孔准直器的内在、系统和断层扫描性能。模型是根据 NEMA 规范制造的，但存在涉及高分辨率修改的偏差。 GATE 用于对带有单针孔准直器的探测器头进行建模，并采用 NEMA 测量来调整和验证模型。单针孔和多针孔 SPECT 数据分别用断层图像重建软件和 HiSPECT 重建。由于高分辨率 SiPM 阵列与 3 毫米厚的闪烁晶体相结合，极限固有分辨率测量为 0.85 毫米。单针孔准直器和多针孔准直器的平均极限断层扫描分辨率分别为 1.37 毫米和 1.19 毫米，其旋转中心的放大系数接近一致。最大观测计数率为 15,400 cps，在单针孔准直器和多针孔准直器的旋转中心测得的平面灵敏度分别为 34 cps/MBq 和 150 cps/MBq。所有模拟测试与测量结果吻合良好，最大偏差均低于 7%。 NEMA NU 1-2018 标准确定 SiPM 探测器可以减少对高放大针孔准直器的需求，同时保留投影图像中的详细信息。测量和模拟的 NEMA 结果具有高度可比性，差异约为百分之几，证实了模拟的准确性并验证了 GATE 模型。 Spark最初提供的准直器中，多针孔准直器可为小动物的器官特异性成像提供高分辨率和灵敏度，单针孔准直器可实现小动物的高分辨率全身成像。
The Cubresa Spark is a novel benchtop silicon-photomultiplier (SiPM)-based preclinical SPECT system. SiPMs in SPECT significantly improve resolution and reduce detector size compared to preclinical cameras with photomultiplier tubes requiring highly magnifying collimators. The NEMA NU 1 Standard for Performance Measurements of Gamma Cameras provides methods that can be readily applied or extended to characterize preclinical cameras with minor modifications. The primary objective of this study is to characterize the Spark according to the NEMA NU 1-2018 standard to gain insight into its nuclear medicine imaging capabilities. The secondary objective is to validate a GATE Monte Carlo simulation model of the Spark for use in preclinical SPECT studies. NEMA NU 1-2018 guidelines were applied to characterize the Spark’s intrinsic, system, and tomographic performance with single- and multi-pinhole collimators. Phantoms were fabricated according to NEMA specifications with deviations involving high-resolution modifications. GATE was utilized to model the detector head with the single-pinhole collimator, and NEMA measurements were employed to tune and validate the model. Single-pinhole and multi-pinhole SPECT data were reconstructed with the Software for Tomographic Image Reconstruction and HiSPECT, respectively. The limiting intrinsic resolution was measured as 0.85 mm owing to a high-resolution SiPM array combined with a 3 mm-thick scintillation crystal. The average limiting tomographic resolution was 1.37 mm and 1.19 mm for the single- and multi-pinhole collimators, respectively, which have magnification factors near unity at the center of rotation. The maximum observed count rate was 15,400 cps, and planar sensitivities of 34 cps/MBq and 150 cps/MBq were measured at the center of rotation for the single- and multi-pinhole collimators, respectively. All simulated tests agreed well with measurement, where the most considerable deviations were below 7%. NEMA NU 1-2018 standards determined that a SiPM detector mitigates the need for highly magnifying pinhole collimators while preserving detailed information in projection images. Measured and simulated NEMA results were highly comparable with differences on the order of a few percent, confirming simulation accuracy and validating the GATE model. Of the collimators initially provided with the Spark, the multi-pinhole collimator offers high resolution and sensitivity for organ-specific imaging of small animals, and the single-pinhole collimator enables high-resolution whole-body imaging of small animals.
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影响因子：
2.1
作者：
Moji V;Zeratkar N;Farahani MH;Aghamiri MR;Sajedi S;Teimourian B;Ghafarian P;Sarkar S;Ay MR
通讯作者：
Ay MR
影响因子：
5.5
作者：
Gomes Marin, Jose Flavio;Nunes, Rafael F.;Buchpiguel, Carlos A.
通讯作者：
Buchpiguel, Carlos A.
DOI：
10.1016/s0168-9002(97)00048-x
发表时间：
1997-04-11
影响因子：
1.4
作者：
Brun, R;Rademakers, F
通讯作者：
Rademakers, F
DOI：
10.1016/j.nima.2016.06.125
发表时间：
2016-11-01
影响因子：
1.4
作者：
Allison, J.;Amako, K.;Yoshida, H.
通讯作者：
Yoshida, H.
影响因子：
10.6
作者：
Lukas, Mathias;Kluge, Anne;Brenner, Winfried
通讯作者：
Brenner, Winfried